Clinical Significance of Increased Cardiac Troponin T in Patients with Chronic Hemodialysis and Cardiovascular Disease: Comparison to B-Type Natriuretic Peptide and A-Type Natriuretic Peptide Increase

Autor: Tadashi Ashida, Shunichi Miyazaki, Naoya Matsumoto, Shinsuke Harasawa, Yoshitaka Iwanaga, Shinichiro Niizuma, Takehiko Washio
Rok vydání: 2019
Předmět:
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
Acute coronary syndrome
medicine.drug_class
medicine.medical_treatment
030232 urology & nephrology
Heart failure
lcsh:RC870-923
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Troponin T
Troponin complex
Renal Dialysis
Internal medicine
Natriuretic Peptide
Brain
lcsh:Dermatology
Natriuretic peptide
medicine
Humans
End-diastolic pressure
Cardiac troponin T
Aged
business.industry
General Medicine
lcsh:RL1-803
lcsh:Diseases of the genitourinary system. Urology
medicine.disease
New York Heart Association Functional Classification
Preload
Cardiovascular Diseases
B-type natriuretic peptide
lcsh:RC666-701
Nephrology
Hemodialysis
Chronic Disease
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Zdroj: Kidney & Blood Pressure Research, Pp 1-13 (2019)
ISSN: 1423-0143
1420-4096
DOI: 10.1159/000502232
Popis: Background: An increased cardiac troponin T (cTnT) level identifies a high-risk group in patients with end-stage renal disease; however, the mechanism of cTnT elevation remains unclear in such patients without acute coronary syndrome (ACS). Therefore, we explored the relationship between cTnT levels and the hemodynamic parameters and the prognostic potential of cTnT in stable patients with chronic hemodialysis (HD). Methods: We included consecutive 174 patients with HD who were referred for coronary angiography due to stable coronary artery disease (CAD), peripheral artery disease (PAD), or heart failure (HF). Hemodynamic measurement was performed, and plasma cTnT, B-type natriuretic peptide (BNP), and A-type natriuretic peptide (ANP) were measured at the same time. The potential of 3 biomarkers to predict all-cause mortality, cardiac death or hospitalized HF, and vascular event was assessed. Results: Increased log cTnT levels were correlated with increased log BNP and log ANP levels (r = 0.531, p < 0.001 and r = 0.411, p < 0.001, respectively). Not increased log cTnT, but increased log BNP and log ANP were associated with the presence of CAD and the extent of CAD. In contrast, they were all associated with the New York Heart Association functional classification and the presence of PAD and significantly correlated with left ventricular end-diastolic pressure (LVEDP) in an independent manner. Increased cTnT and BNP levels were associated with the mortality and hospitalized HF. However, increased cTnT was not associated with vascular events, unlike increased BNP. Conclusions: In patients with chronic HD without ACS, increased cTnT reflected increased LVEDP and the presence of HF or PAD independently, and it did not reflect the presence of CAD in contrast to increased BNP. cTnT and BNP were significant prognostic predictors; however, increased cTnT was associated with HF-related events, not with arteriosclerotic events.
Databáze: OpenAIRE
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