Incidence of fractures among patients receiving medications for type 2 diabetes or chronic obstructive pulmonary disease and glucocorticoid users according to the National Claims Database in Japan
| Autor: | Saeko Fujiwara, Nobukazu Okimoto, Shigeyuki Ishii, Takahiko Hamasaki |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty 030209 endocrinology & metabolism Type 2 diabetes Hip fracture Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Japan Risk Factors Internal medicine Diabetes mellitus Radial fracture Clinical vertebral fracture medicine Humans Orthopedics and Sports Medicine Glucocorticoids COPD Hip Fractures business.industry Chronic obstructive pulmonary disease Incidence Incidence (epidemiology) Middle Aged medicine.disease Confidence interval Middle age Diabetes Mellitus Type 2 Orthopedic surgery Original Article Female 030101 anatomy & morphology business |
| Zdroj: | Archives of Osteoporosis |
| ISSN: | 1862-3514 1862-3522 |
| DOI: | 10.1007/s11657-021-00968-9 |
| Popis: | Summary According to information from the National Health Insurance and Claims database, the risk for hip, radius, and clinical vertebral fractures was higher among patients receiving medication for type 2 diabetes, COPD, or glucocorticoids than among the whole Japanese population after middle age. Purpose The aim of this study was to determine the incidence of fractures among patients receiving medications for type 2 diabetes or chronic obstructive pulmonary disease (COPD) and using glucocorticoids (GC) according to the National Database of Health Insurance Claims (NDB) in Japan. Methods We obtained data on the number of fractures and patients receiving medications for type 2 diabetes, COPD, or GC from the NDB. The claims data included sex, age group, injury/illness name, hospitalization, outpatient, surgery/medical treatment, and drugs used between January and December 2017. Results The risk of hip fracture was higher among patients receiving medications for diabetes or COPD and GC users than in the Japanese population, with standardized incidence ratios (SIRs) of 1.71 (95% confidence interval [CI]1.6–1.75), 1.35 (95% CI 1.28–1.42), and 1.62 (95% CI 1.53–1.71) in men and 1.81 (95% CI 1.79–1.84), 1.67 (95% CI 1.54–1.80), and 1.71 (95% CI 1.66–1.76) in women, respectively. There was also a significantly higher incidence of radial fractures in women and clinical vertebral fractures in both men and women. A greater risk of hip fracture was found among diabetic patients starting in their late 40 s. Conclusions Real-world data revealed that the incidence of hip, radius, and clinical vertebral fractures was significantly higher among patients receiving medications for diabetes or COPD and GC users than in the Japanese population after middle age. |
| Databáze: | OpenAIRE |
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