Treatment of Cutaneous Melanoma of the Head and Neck With Wide Local Excision Versus Mohs
| Autor: | Laura M. Dooley, Arya W. Namin, Edouard M. Oudin, Patrick Tassone, Robert P. Zitsch, Tabitha L.I. Galloway |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms medicine.medical_treatment Sentinel lymph node Kaplan-Meier Estimate 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Biopsy medicine Humans Head and neck Melanoma Retrospective Studies medicine.diagnostic_test Sentinel Lymph Node Biopsy business.industry Wide local excision Margins of Excision Cancer Retrospective cohort study Mohs Surgery medicine.disease Surgery Treatment Outcome Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Cutaneous melanoma Female Sentinel Lymph Node business |
| Zdroj: | The Laryngoscope. 131:2490-2496 |
| ISSN: | 1531-4995 0023-852X |
| Popis: | OBJECTIVES Determine if Mohs micrographic surgery (MMS) is associated with improved overall survival compared to wide local excision (WLE) when treating cutaneous melanoma of the head and neck (CMHN) and to report the proportion of patients treated with MMS versus WLE who also underwent sentinel lymph node biopsy (SLNB). METHODS Retrospective cohort study of the National Cancer Database (NCDB) analyzing the overall survival of patients diagnosed with T1 to T4 CMHN between 2004 and 2016 who were treated with either WLE or MMS. RESULTS On multivariable analysis, treatment with WLE versus MMS was not significantly associated with overall survival (HR, 1.094; 95% CI, 0.997-1.201). On multivariable analysis, lower Charlson-Deyo score (HR, 0.489; 95% CI, 0.427-0.560), negative margins (HR, 0.754; 95% CI, 0.705-0.807), and N0 classification (HR 0.698; 95% CI, 0.668-0.730) were associated with improved overall survival. Seventy-seven percent of patients treated with MMS did not undergo SLNB, while 45% of patients treated with WLE did not undergo SLNB (P |
| Databáze: | OpenAIRE |
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