Survival Impact of Optimal Surgical Cytoreduction in Recurrent Epithelial Ovarian Cancer with Brain Metastasis

Autor:	Pinar Saip, Banu Atalar, Serkan Keskin, Hamdullah Sozen, Seden Kucucuk, Kamuran Ibis, Naziye Ak, Samet Topuz, Murat Sari
Rok vydání:	2019
Předmět:	Adult Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment Central nervous system Disease Carcinoma Ovarian Epithelial Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine Ovarian carcinoma medicine Humans Epithelial ovarian cancer 030212 general & internal medicine Aged Neoplasm Staging Retrospective Studies Ovarian Neoplasms Univariate analysis Brain Neoplasms business.industry Brain Cytoreduction Surgical Procedures Hematology Middle Aged Prognosis medicine.disease Radiation therapy Treatment Outcome medicine.anatomical_structure 030220 oncology & carcinogenesis Female Radiotherapy Adjuvant Neoplasm Recurrence Local business Follow-Up Studies Brain metastasis
Zdroj:	Oncology Research and Treatment. 42:101-106
ISSN:	2296-5262 2296-5270
Popis:	Aim: The aim of this study was to determine the clinicopathological characteristics, treatment details and outcome of patients with brain metastasis from epithelial ovarian carcinoma (EOC). Methods: This study included 21 patients diagnosed with brain metastasis from EOC between 1999 and 2009. Results: Median age was 61 years (range 38-77). The median time elapsed from EOC diagnosis to brain metastasis detection was 32 months. Single brain metastases were found in 10 (48%) cases, and there was extra-cranial disease in 11 (52%) cases. During the mean 86 months of follow-up, 18 of the patients (86%) died of the disease and 3 (14%) were alive with disease. The median survival time after the initial diagnosis of brain metastasis was 9 months. The median overall survival (OS) from initial diagnosis of EOC was 50 months. In univariate analysis, prolonged time from initial diagnosis to central nervous system metastasis (more than 32 months) (p = 0.001), treatment with radiotherapy (p < 0.001), optimal cytoreductive operation (p = 0.02) were all positively correlated with OS. Conclusion: The prognosis of patients with brain metastasis from EOC is still poor. The significant predictors of survival in our series were whole brain radiotherapy, prolonged elapsed time from initial diagnosis to brain metastasis and optimal cytoreductive surgery.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4487260e403414549cb32662ed0d6423 https://doi.org/10.1159/000494334 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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