Systemic Circulatory Parameters Comparison Between Patients with Normal Tension Glaucoma and Normal Subjects Using Ambulatory Monitoring
| Autor: | Osamu Hosaka, Kenji Kashiwagi, Hiroyuki Ishii, Kazuyuki Taguchi, Hiroshi Ijiri, Jun Mochizuki, Fumiko Kashiwagi, Koji Tamura, Shigeo Tsukahara |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Aging medicine.medical_specialty Ambulatory blood pressure genetic structures Glaucoma Blood Pressure Sex Factors Heart Rate Internal medicine Normal tension glaucoma medicine Humans Circadian rhythm Aged Aged 80 and over business.industry General Medicine Blood Pressure Monitoring Ambulatory Middle Aged medicine.disease eye diseases Circadian Rhythm Surgery Low Tension Glaucoma Ophthalmology Blood pressure Circulatory system Ambulatory Cardiology Female sense organs Visual Fields business Glaucoma Open-Angle |
| Zdroj: | Japanese Journal of Ophthalmology. 45:388-396 |
| ISSN: | 0021-5155 |
| Popis: | Purpose: To compare circadian changes of systemic circulation in patients with normal tension glaucoma (NTG) and normal subjects. Methods: Forty-three patients with NTG and 226 normal subjects were enrolled in this study. Circulatory parameters, including blood pressure (BP) and pulse rate (PR), were measured in all subjects for 49 hours using an ambulatory monitoring system. In addition to a comparison between NTG patients and normal controls, the same parameters were compared between NTG patients who had progressive field defects and NTG patients who had stable field defects. Results: The BP in NTG patients was significantly higher than in normal subjects. The nocturnal dip of BP in NTG patients was similar to the dip in normal subjects. However, the BP dip in NTG patients showing progressive visual field defects was significantly smaller than in patients with NTG showing stable visual field defects. Blood pressure fluctuation in sleep in the “progressive” patients was significantly greater than in the “stable” patients. Patients with NTG whose random BP was in a normal range showed a higher BP than normal subjects. The dip in PR in NTG patients was significantly lower than in normal subjects. Conclusions: An insufficient physiological nocturnal BP dip or a greater nocturnal fluctuation in BP may disturb the microcirculation of, and/or may directly damage, the optic nerve, resulting in increasing field loss in NTG. |
| Databáze: | OpenAIRE |
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