A Case of Pathophysiologic Study in Kimura's Disease: Measurement of Cytokines and Surface Analysis of Eosinophils
| Autor: | Tomoyasu Momose, Shiro Horie, Yoshio Okubo, Morie Sekiguchi, Kendo Kiyosawa, Akihiro Tsukadaira, Susumu Itoh, Kiyoshi Kitano, Makoto Ito, Shuji Takashi |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Integrins Systemic disease Pathology medicine.medical_specialty medicine.medical_treatment Immunology Receptors Lymphocyte Homing Macrophage-1 Antigen Enzyme-Linked Immunosorbent Assay Disease Integrin alpha4beta1 Tetraspanin 29 Pathogenesis Leukocyte Count Antigens CD Eosinophil activation medicine Humans Immunology and Allergy Aged Membrane Glycoproteins business.industry Receptors IgG Angiolymphoid Hyperplasia with Eosinophilia Receptors Interleukin-2 Eosinophil Flow Cytometry medicine.disease Eosinophils medicine.anatomical_structure Cytokine Solubility Antigens Surface Cytokines Kimura's disease Tumor necrosis factor alpha business |
| Zdroj: | Annals of Allergy, Asthma & Immunology. 81:423-427 |
| ISSN: | 1081-1206 |
| Popis: | Background Kimura's disease is a rare but distinctive eosinophilic inflammatory disorder of unknown etiology; few reported case studies have focused on the immunopathologic background of this unique disease. Objective To define better the immunopathogenetic features of Kimura's disease, we attempted to quantitatively analyze values of cytokines and soluble interleukin-2 receptor (sIL-2R) in peripheral blood (PB), as well as perform surface immunophenotypic analysis of eosinophils from a Japanaese patient with chronic relapsing Kimura's disease. Results Granulocyte macrophage-colony stimulating factor (GM-CSF), tumor necrosis factor-alpha (TNF-alpha) and sIL-2R were elevated, and newly expressed antigens on eosinophils CD4, CD25, and HLA-DR were found to be involved in the pathophysiology of this disorder. Conclusions Kimura's disease may be a disease in which activated lymphocytes release cytokines, and these released cytokines, such as GM-CSF and TNF-alpha cause eosinophil activation. These processes may be related to the pathogenesis of this disorder. |
| Databáze: | OpenAIRE |
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