A Regions of Interest Voxel-Based Morphometry Study of the Human Brain During High-Frequency Spinal Cord Stimulation in Patients With Failed Back Surgery Syndrome

Autor: Félix Buyck, Ronald Peeters, Peter Van Schuerbeek, Stefan Sunaert, Mats De Jaeger, Maarten Moens, Philippe Rigoard, Bengt Linderoth, Lisa Goudman, Sander De Groote
Přispěvatelé: Faculty of Medicine and Pharmacy, Neurosurgery, Pain in Motion, Artificial Intelligence supported Modelling in clinical Sciences, Supporting clinical sciences, Medical Imaging, Radiology, Neuroprotection & Neuromodulation
Rok vydání: 2020
Předmět:
Adult
Male
Neuroscience(all)
neuroplasticity
Grey matter
computer.software_genre
structural brain alterations
Structural brain alterations
surgery
03 medical and health sciences
0302 clinical medicine
Regions of Interest Voxel-Based Morphometry
030202 anesthesiology
Voxel
Neuroplasticity
medicine
Back pain
Humans
Failed Back Surgery Syndrome
Aged
Spinal Cord Stimulation
integumentary system
medicine.diagnostic_test
business.industry
Chronic pain
Brain
Magnetic resonance imaging
Voxel-based morphometry
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Anesthesiology and Pain Medicine
medicine.anatomical_structure
Treatment Outcome
nervous system
Anesthesia
regions-of-interest voxel-based morphometry
Pain catastrophizing
Female
sense organs
medicine.symptom
Chronic Pain
business
tissues
computer
030217 neurology & neurosurgery
Zdroj: Pain practice : the official journal of World Institute of PainReferences. 20(8)
ISSN: 1533-2500
Popis: INTRODUCTION: The effectiveness of spinal cord stimulation (SCS) as pain-relieving treatment for failed back surgery syndrome (FBSS) has already been demonstrated. However, potential structural and functional brain alterations resulting from subsensory SCS are less clear. The aim of this study was to test structural volumetric changes in a priori chosen regions of interest related to chronic pain after 1 month and 3 months of high-frequency SCS in patients with FBSS. METHODS: Eleven patients with FBSS who were scheduled for SCS device implantation were included in this study. All patients underwent a magnetic resonance imaging protocol before SCS device implantation 1 and 3 months after high-frequency SCS. Pain intensity, pain catastrophizing, and sleep quality were also measured. Regions-of-interest voxel-based morphometry was used to explore grey matter volumetric changes over time. Additionally, volumetric changes were correlated with changes in pain intensity, catastrophizing, and sleep quality. RESULTS: Significant decreases were found in volume in the left and right hippocampus over time. More specifically, a significant difference was revealed between volumes before SCS implantation and after 3 months of SCS. Repeated-measures correlations revealed a significant positive correlation between volumetric changes in the left hippocampus and changes in back pain score over time and between volumetric changes in the right hippocampus and changes in back pain score over time. CONCLUSION: In patients with FBSS, high-frequency SCS influences structural brain regions over time. The volume of the hippocampus was decreased bilaterally after 3 months of high-frequency SCS with a positive correlation with back pain intensity. ispartof: Pain Practice vol:20 issue:8 pages:878-888 ispartof: location:United States status: published
Databáze: OpenAIRE
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