α2-adrenoceptor binding in Flinders-sensitive line compared with Flinders-resistant line and Sprague-Dawley rats
| Autor: | Peter Iversen, Thea P. Lillethorup, Gregers Wegener, D. Doudet, Anne M. Landau |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adrenergic Neurons
medicine.medical_specialty Biology Rats Sprague-Dawley α2 adrenoceptor Animal model Idazoxan Receptors Adrenergic alpha-2 Internal medicine medicine Sprague dawley rats Animals Biological Psychiatry Depression (differential diagnoses) Adrenergic alpha-Antagonists Depression Brain Rat brain Pathophysiology Rats Psychiatry and Mental health Disease Models Animal Endocrinology Autoradiography Female Protein Binding |
| Zdroj: | Lillethorup, T P, Iversen, P, Wegener, G, Doudet, D J M & Landau, A M 2015, ' α2-adrenoceptor binding in Flinders-sensitive line compared with Flinders-resistant line and Sprague-Dawley rats ', Acta Neuropsychiatrica , pp. 1-8 . https://doi.org/10.1017/neu.2015.24 |
| ISSN: | 0924-2708 |
| DOI: | 10.1017/neu.2015.24 |
| Popis: | ObjectivesDisturbances in the noradrenergic system, including alterations in the densities of α2-adrenoceptors, are posited to be involved in the pathophysiology of depression. In this study, we investigate the binding of α2-adrenoceptors in regions relevant to depression in an animal model of depression.MethodsUsing in vitro autoradiography techniques and the selective α2-ligand, [3H]RX 821002, we investigated the density of α2-adrenoceptors in female Flinders-sensitive line (FSL) rats, a validated model of depression, and in two traditional control groups – female Flinders-resistant line (FRL) and Sprague-Dawley (SD) rats.ResultsThe α2-adrenoceptor density was increased in most regions of the FSL rat brain when compared with SD rats (10% across regions). Moreover, the α2-adrenoceptor density was further increased in the FRL rats compared with both FSL (10% across regions) and SD rats (24% across regions).ConclusionsThe increase in α2-adrenoceptor binding in cortical regions in the FSL strain compared with the SD control strain is in accord with α2-adrenoceptor post-mortem binding data in suicide victims with untreated major depression. However, the differences in binding observed in the two control groups were unexpected and suggest the need for further studies in a larger cohort of animals of both sexes. |
| Databáze: | OpenAIRE |
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