Reversal of theta rhythm flow through intact hippocampal circuits
| Autor: | Jesse Jackson, Steven L. Bressler, Sylvain Williams, Bénédicte Amilhon, Christian Kortleven, Frédéric Manseau, Jean-Bastien Bott, Romain Goutagny |
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| Přispěvatelé: | Douglas Mental Health University Institute [Montréal], McGill University = Université McGill [Montréal, Canada], Laboratoire de neurosciences cognitives et adaptatives (LNCA), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2014 |
| Předmět: |
Male
Time Factors Vesicular Inhibitory Amino Acid Transport Proteins Hippocampus Action Potentials Optogenetics Hippocampal formation In Vitro Techniques Inhibitory postsynaptic potential Rats Sprague-Dawley Animals Theta Rhythm Evoked Potentials ComputingMilieux_MISCELLANEOUS gamma-Aminobutyric Acid musculoskeletal neural and ocular physiology General Neuroscience Subiculum Electric Stimulation Rats Luminescent Proteins Parvalbumins nervous system Animals Newborn Excitatory postsynaptic potential GABAergic [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Female Synaptic signaling Nerve Net Psychology Neuroscience |
| Zdroj: | Nature Neuroscience Nature Neuroscience, Nature Publishing Group, 2014, 17 (10), pp.1362-1370. ⟨10.1038/nn.3803⟩ |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/nn.3803⟩ |
| Popis: | Activity flow through the hippocampus is thought to arise exclusively from unidirectional excitatory synaptic signaling from CA3 to CA1 to the subiculum. Theta rhythms are important for hippocampal synchronization during episodic memory processing; thus, it is assumed that theta rhythms follow these excitatory feedforward circuits. To the contrary, we found that theta rhythms generated in the rat subiculum flowed backward to actively modulate spike timing and local network rhythms in CA1 and CA3. This reversed signaling involved GABAergic mechanisms. However, when hippocampal circuits were physically limited to a lamellar slab, CA3 outputs synchronized CA1 and the subiculum using excitatory mechanisms, as predicted by classic hippocampal models. Finally, analysis of in vivo recordings revealed that this reversed theta flow was most prominent during REM sleep. These data demonstrate that communication between CA3, CA1 and the subiculum is not exclusively unidirectional or excitatory and that reversed inhibitory theta signaling also contributes to intrahippocampal synchrony. |
| Databáze: | OpenAIRE |
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