Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain

Autor:	Brande S. Williams, Mathew J. Wyvratt, Sriram Tyagarajan, Vivien A. Warren, Catherine Abbadie, Brett Taylor, William J. Martin, Xiaohua Li, William H. Parsons, Nina Jochnowitz, Erin McGowan, Sanjeev Kumar, Ann E. Weber, Gregory J. Kaczorowski, Michael H. Fisher, Bishan Zhou, John P. Felix, Tracy Klatt, McHardy M. Smith, Birgit T. Priest, Prasun K. Chakravarty, Kathryn A. Lyons, Joseph L. Duffy, Ronsar Eid, Maria L. Garcia, Richard M. Brochu
Rok vydání:	2010
Předmět:	Stereochemistry Clinical Biochemistry Analgesic Drug Evaluation Preclinical Biphenyl derivatives Pharmaceutical Science Motor Activity Pyrazole Pharmacology Biochemistry Sodium Channels Mice chemistry.chemical_compound Dogs Sodium channel blocker Drug Discovery Animals Humans Spinal nerve ligation Molecular Biology Biphenyl Compounds Organic Chemistry Metabolic stability Rats Liver metabolism chemistry Neuropathic pain Microsomes Liver Neuralgia Pyrazoles Molecular Medicine Sodium Channel Blockers
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 20:7479-7482
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2010.10.017
Popis:	A series of novel biphenyl pyrazole dicarboxamides were identified as potential sodium channel blockers for treatment of neuropathic pain. Compound 20 had outstanding efficacy in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44809e16a6cd04e26b06d5a57716c59e https://doi.org/10.1016/j.bmcl.2010.10.017 Zobrazit plný text záznamu Full Text from ScienceDirect