Breast-conserving surgery for T3/T4 breast cancer: an analysis of 196 patients
| Autor: | Günther G. Steger, W. Draxler, Peter Dubsky, Florian Fitzal, Ursula Pluschnig, Leonore Handl-Zeller, Margaretha Rudas, Thomas Bachleitner-Hofmann, Raimund Jakesz, Michael Gnant, Lisa Wutzl, O. Riedl |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment Mammary gland Breast Neoplasms Mastectomy Segmental Disease-Free Survival Breast cancer Internal medicine medicine Breast-conserving surgery Humans skin and connective tissue diseases Mastectomy Survival analysis Aged Retrospective Studies Aged 80 and over business.industry Cancer Retrospective cohort study Middle Aged medicine.disease Survival Analysis Surgery Radiation therapy medicine.anatomical_structure Female Radiotherapy Adjuvant business |
| Zdroj: | Breast Cancer Research and Treatment. 103:45-52 |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-006-9325-6 |
| Popis: | Breast conservation therapy (BCT) increases quality of life and self-esteem of breast cancer patients. In special cancer centers up to 90% of patients are treated with BCT. T3/T4 breast cancer is one of the few contraindications for BCT. However, retrospective data suggest that BCT may be eligible in selected cases of T3/T4 breast cancer.We analyzed retrospectively 196 breast cancer patients (operated between 1995 and 2004) suffering from T3/T4 tumors and compared BCT and radiotherapy with mastectomy in these patients in terms of overall survival (OS), local recurrence free-survival (LRFS) and breast cancer-related death (BCRD).Demographic data showed no significant differences in prognostic factors between patients treated with mastectomy compared with BCT. Kaplan-Meier curves demonstrated no significant difference for OS, LRFS and BCRD between the two groups.Our data strongly suggest that BCT with R0 resection followed by radiotherapy is feasible in patients with T3/T4 breast cancer. Prospective studies have to be performed to further investigate this issue. |
| Databáze: | OpenAIRE |
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