Time-dependent and tissue-specific effects of circulating glucose on fetal ovine glucose transporters
| Autor: | Robert E Schroeder, William W. Hay, Sherin U. Devaskar, Utpala G. Das |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Blood Glucose
endocrine system medicine.medical_specialty Time Factors endocrine system diseases Monosaccharide Transport Proteins Physiology medicine.medical_treatment Adipose tissue Muscle Proteins Nerve Tissue Proteins Hypoglycemia Biology Insulin resistance Fetus Pregnancy Physiology (medical) Internal medicine medicine Animals Insulin Tissue Distribution Glucose Transporter Type 1 Glucose Transporter Type 4 Sheep Glucose Transporter Type 3 Osmolar Concentration Glucose transporter nutritional and metabolic diseases Skeletal muscle medicine.disease Fetal Blood carbohydrates (lipids) Pregnancy Complications Endocrinology medicine.anatomical_structure Basal (medicine) Hyperglycemia Female hormones hormone substitutes and hormone antagonists |
| Zdroj: | The American journal of physiology. 276(3) |
| ISSN: | 0002-9513 |
| Popis: | To determine the cellular adaptations to fetal hyperglycemia and hypoglycemia, we examined the time-dependent effects on basal (GLUT-1 and GLUT-3) and insulin-responsive (GLUT-4) glucose transporter proteins by quantitative Western blot analysis in fetal ovine insulin-insensitive (brain and liver) and insulin-sensitive (myocardium, skeletal muscle, and adipose) tissues. Maternal glucose infusions causing fetal hyperglycemia resulted in a transient 30% increase in brain GLUT-1 but not GLUT-3 levels and a decline in liver and adipose GLUT-1 and myocardial and skeletal muscle GLUT-1 and GLUT-4 levels compared with gestational age-matched controls. Maternal insulin infusions leading to fetal hypoglycemia caused a decline in brain GLUT-3, an increase in brain GLUT-1, and a subsequent decline in liver GLUT-1, with no significant change in insulin-sensitive myocardium, skeletal muscle, and adipose tissue GLUT-1 or GLUT-4 concentrations, compared with gestational age-matched sham controls. We conclude that fetal glucose transporters are subject to a time-dependent and tissue- and isoform-specific differential regulation in response to altered circulating glucose and/or insulin concentrations. These cellular adaptations in GLUT-1 (and GLUT-3) are geared toward protecting the conceptus from perturbations in substrate availability, and the adaptations in GLUT-4 are geared toward development of fetal insulin resistance. |
| Databáze: | OpenAIRE |
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