Epidemiology of fungaemia in Sweden: A nationwide retrospective observational survey

Autor:	Cecilia Jendle Bengten, Johan Rydberg, Gunnar Kahlmeter, Eva Törnqvist, Minna Ygge, Nahid Kondori, Jonas Swanberg, Karin Kindlund, Måns Ullberg, Lena Klingspor, Eva Halldin, Lena Serrander, Marcus Johansson, Kenneth Nilsson, Margareta Granlund, Dalila Kartout-Boukdir, Anders Nyberg, Michael Toepfer, Volkan Özenci
Rok vydání:	2018
Předmět:	Adult Male 0301 basic medicine Antifungal Agents Adolescent 030106 microbiology Population Microbial Sensitivity Tests Dermatology Microbiology Young Adult 03 medical and health sciences 0302 clinical medicine Drug Resistance Fungal medicine Humans Blood culture 030212 general & internal medicine Child Candida albicans education Aged Candida Retrospective Studies Aged 80 and over Sweden Voriconazole education.field_of_study Candida glabrata biology medicine.diagnostic_test business.industry Incidence Infant Newborn Candidemia Infant General Medicine Middle Aged bacterial infections and mycoses biology.organism_classification Corpus albicans Meningitis Fungal Infectious Diseases Child Preschool Anidulafungin Female business Fluconazole medicine.drug
Zdroj:	Mycoses. 61:777-785
ISSN:	0933-7407 2005-2006
Popis:	Objectives: To identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates to identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates in Sweden. Methods: The study was a retrospective, observational nationwide laboratory-based surveillance for fungaemia and fungal meningitis and was conducted from September 2015 to August 2016. Results: In total, 488 Candida blood culture isolates were obtained from 471 patients (58% males). Compared to our previous study, the incidence of candidaemia has increased from 4.2/100 000 (2005-2006) to 4.7/100 000 population/year (2015-2016). The three most common Candida spp. isolated from blood cultures were Candida albicans (54.7%), Candida glabrata (19.7%) and species in the Candida parapsilosis complex (9.4%). Candida resistance to fluconazole was 2% in C. albicans and between 0% and 100%, in non-albicans species other than C. glabrata and C. krusei. Resistance to voriconazole was rare, except for C. glabrata, C. krusei and C. tropicalis. Resistance to anidulafungin was 3.8% while no Candida isolate was resistant to amphotericin B. Conclusions: We report an overall increase in candidaemia but a minor decrease of C. albicans while C. glabrata and C. parapsilosis remain constant over this 10-year period. (Less)
Databáze:	OpenAIRE
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