Acute hepatic injury after the withdrawal of immunosuppressive chemotherapy in patients with hepatitis B
| Autor: | Lauren Pinter-Brown, Sugantha Govindarajan, Eddie Hu, Paul C. Pinto, Marjorie Bernstein-Singer |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Lymphoma medicine.drug_class medicine.medical_treatment medicine.disease_cause Gastroenterology Liver Function Tests Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Hepatitis B virus Chemotherapy Hepatitis B Surface Antigens business.industry Lymphoma Non-Hodgkin Immunosuppression Middle Aged Hepatitis B medicine.disease Hodgkin Disease Leukemia Lymphocytic Chronic B-Cell Pathophysiology Liver Oncology Chronic Disease Immunology Prednisone Corticosteroid Female Viral disease Complication business |
| Zdroj: | Cancer. 65:878-884 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19900215)65:4<878::aid-cncr2820650409>3.0.co;2-k |
| Popis: | Five patients with lymphoproliferative malignancies and chronic hepatitis B suffered severe acute hepatic injury after the withdrawal of multiagent chemotherapy that included high-dose corticosteroid. Four patients died of hepatic failure, three of whom received corticosteroid as treatment for the hepatic injury. We believe that the cause of this entity is massive immune-associated cytolysis of hepatitis B virus infected hepatocytes occurring after a period of immunosuppression and increased viral replication. The literature regarding this complication of chemotherapy and its pathophysiology is reviewed. |
| Databáze: | OpenAIRE |
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