Differences in Placental Histology Between Zika Virus-infected Teenagers and Older Women
Autor: | Antoni S Arandes, Clovis Antonio Lopes Pinto, Raphael Cruz Seabra Prudente, Mayana Zatz, Laura C. Rodrigues, Eduardo Massad, Saulo Duarte Passos, Steven S. Witkin, Geovane Ribeiro dos Santos |
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Rok vydání: | 2021 |
Předmět: |
Pathology
medicine.medical_specialty Microcephaly Adolescent Placenta Physiology Chorioamnionitis Umbilical cord Pathology and Forensic Medicine Zika virus Pregnancy medicine Humans Pregnancy Complications Infectious Aged Fetus biology business.industry Zika Virus Infection Obstetrics and Gynecology Zika Virus medicine.disease biology.organism_classification medicine.anatomical_structure Cyclooxygenase 2 Hofbauer cell Female business |
Zdroj: | International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 41(4) |
ISSN: | 1538-7151 |
Popis: | In pregnant women, Zika virus (ZIKV) is associated with a congenital syndrome, most frequently involving damage to embryo brain formation and the development of microcephaly. The mechanism(s) by which ZIKV enters the maternal-fetal interface and is transmitted to the fetus remains incompletely determined. We sought to evaluate histologic changes in the placenta of ZIKV-infected pregnant women and to determine if this varied by maternal age. Placental samples were obtained from 66 women, 33 of whom were positive for ZIKV. Histologic evaluations were performed on 4 areas of the placenta: fetal surface, maternal surface, umbilical cord, and membranes. Samples were analyzed by the tissue microarray technique and tested for CD4, CD8, CD20, CD68, FOXP3, and cyclooxygenase-2 expression. Data were evaluated using Fisher exact test. ZIKV infection was more frequent in women less than 18 yr of age (9/11, 81.8%) than in women above 18 yr old (24/55, 43.6%) (P=0.0440). ZIKV detection was associated with neutrophilic chorioamnionitis (P=0.0332) and with septal (P=0.0244) and villous (P=0.0534) calcification. Hofbauer cell hyperplasia (P=0.0260) and cyclooxygenase-2 expression (P=0.0346) were more prevalent in ZIKV-positive women aged 18 yr and below than in the older ZIKV-positive women. ZIKV infection during pregnancy occurs more frequently in adolescents and induces higher rates of damage at the maternal-fetal interface than in older women. |
Databáze: | OpenAIRE |
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