Antiparkinsonian properties of a nerve growth factor dipeptide mimetic GK-2 in in vivo experiments
| Autor: | S. B. Seredenin, T. A. Gudasheva, P. Yu. Povarnina, N. A. Bondarenko, O. N. Vorontsova |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_treatment Intraperitoneal injection Catalepsy Pharmacology General Biochemistry Genetics and Molecular Biology Antiparkinson Agents chemistry.chemical_compound Mice Parkinsonian Disorders Oral administration In vivo medicine Haloperidol Animals Oxidopamine Dipeptide General Medicine Dipeptides medicine.disease Rats Mice Inbred C57BL Nerve growth factor chemistry Biochemistry 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine medicine.drug |
| Zdroj: | Bulletin of experimental biology and medicine. 151(6) |
| ISSN: | 1573-8221 |
| Popis: | An intraperitoneal injection of GK-2 (dipeptide mimetic of nerve growth factor, 0.01-5.00 mg/kg) 24 h before the adverse exposure reduced the severity of haloperidol-induced catalepsy in rats. This agent retained the activity after oral administration in a dose of 10 mg/kg. An intraperitoneal injection of GK-2 in a dose of 1 mg/kg reduced the severity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian syndrome in mice. Administration of GK-2 45 min after haloperidol treatment was also followed by a decrease in the degree of catalepsy. The repeated intraperitoneal treatment with GK-2 in a dose of 1 mg/kg after intrastriatal injection of 6-hydroxydopamine was shown to prevent the development of apomorphine-induced rotations in rats. |
| Databáze: | OpenAIRE |
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