Publisher Correction: A CD146 FACS Protocol Enriches for Luminal Keratin 14/19 Double Positive Human Breast Progenitors
| Autor: | Ole W. Petersen, Jiyoung Kim, Agla J. Fridriksdottir, Lone Rønnov-Jessen, Mikkel Morsing, Vera Timmermans-Wielenga, Ólöf Gerdur Ísberg, René Villadsen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Keratin 14 Adolescent Carcinogenesis Double negative lcsh:Medicine Breast Neoplasms CD146 Antigen Young Adult Medicine Humans Progenitor cell lcsh:Science Mammary Glands Human Cells Cultured Keratin-19 Multidisciplinary business.industry lcsh:R Keratin-14 Middle Aged Publisher Correction Healthy Volunteers Cancer research Neoplastic Stem Cells CD146 lcsh:Q Female business Human breast |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020) |
| ISSN: | 2045-2322 |
| Popis: | Human breast cancer is believed to arise in luminal progenitors within the normal breast. A subset of these are double positive (DP) for basal and luminal keratins and localizes to a putative stem cell zone within ducts. We here present a new protocol based on a combination of CD146 with CD117 and CD326 which provides an up to thirty fold enrichment of the DP cells. We show by expression profiling, colony formation, and morphogenesis that CD146 |
| Databáze: | OpenAIRE |
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