Immunogenetic Markers Definition in Latvian Patients with Lyme Borreliosis and Lyme Neuroborreliosis
| Autor: | Angelika Krumina, Sandra Gintere, Irina Lucenko, Julija Trofimova, Lilija Kovalchuka, Svetlana Cvetkova, Jelena Eglite, Barbara Oczko-Grzesik, Ludmila Viksna |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
musculoskeletal diseases Adult Adolescent Genotype Lyme neuroborreliosis Health Toxicology and Mutagenesis lcsh:Medicine Human leukocyte antigen Article 03 medical and health sciences Young Adult immunogenetic markers Lyme disease immune system diseases medicine Humans Borrelia burgdorferi Immunogenetic Phenomena skin and connective tissue diseases Genotyping HLA-DRB1 Aged Lyme borreliosis Lyme Disease biology business.industry Incidence (epidemiology) Incidence lcsh:R Public Health Environmental and Occupational Health Middle Aged biology.organism_classification medicine.disease bacterial infections and mycoses Latvia 030104 developmental biology Lyme Neuroborreliosis Immunology business Biomarkers HLA-DRB1 Chains |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 13, Iss 12, p 1194 (2016) International Journal of Environmental Research and Public Health; Volume 13; Issue 12; Pages: 1194 |
| ISSN: | 1660-4601 |
| Popis: | The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction- sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles. The allele -DRB1*11(05), -DRB1*14(06) and -DRB1*13(06) were significantly more frequent in controls. In-group with Lyme neuroborreliosis differences were found for the -DRB1*07 and -DRB1*04 alleles, but only HLA-DRB1*07 allele was statistically significant after Bonferroni correction and associated with Lyme neuroborreliosis in Latvian patients. |
| Databáze: | OpenAIRE |
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