Screening of new bioactive metabolites for diabetes therapy
| Autor: | Kazuo Umezawa, Satoru Todo, Kulrawee Sidthipong, Izumi Takei, Itaru Kojima |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Islets of Langerhans Transplantation Pharmacology Conophylline Diabetes Therapy Fibrosis Internal medicine Precursor cell Diabetes mellitus Insulin-Secreting Cells Internal Medicine medicine Animals Humans Vinca Alkaloids geography geography.geographical_feature_category business.industry Cyclohexanones NF-kappa B Cancer Cell Differentiation medicine.disease Islet Transplantation Endocrinology Diabetes Mellitus Type 1 Benzamides Emergency Medicine business |
| Zdroj: | Internal and emergency medicine. 8 |
| ISSN: | 1970-9366 |
| Popis: | Microorganisms and plants produce bioactive metabolites that are potentially useful in the treatment of disease. We have designed and synthesized DHMEQ as a specific inhibitor of NF-κB based on the structure of epoxyquinomicin. It directly binds to NF-κB components to inhibit DNA-binding and was shown to be endowed with inhibiting activity in various inflammatory and cancer models in experimental animals. It was also effective to improve the success of islet transplantation especially when administered to donor mice. We have also isolated from the leaves of Ervatamia microphylla conophylline, a compound that induces differentiation of beta cells from the precursor cells and was recently found to suppress islet fibrosis in diabetes model rats. |
| Databáze: | OpenAIRE |
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