Zinc phosphate-based nanoparticles as alternatives to zinc oxide in diet of weaned piglets
| Autor: | Lucie Bozdechova, Pavel Nevrkla, Ludek Zurek, Ondrej Zitka, Pavel Horky, Vojtech Adam, Tomas Do, Jaroslava Belkova, Pavel Kopel, Yazan Haddad, Eva Václavková, Daria Baholet, Sylvie Skalickova, Silvia Kociova, Jiri Skladanka, Kristyna Smerkova, Kristyna Dolezelikova |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Antioxidant Aerobic bacteria medicine.medical_treatment chemistry.chemical_element Zinc medicine.disease_cause Biochemistry coli STa 03 medical and health sciences Animal science medicine STb Escherichia coli Feces lcsh:SF1-1100 F18 Antioxidant status Fecal coliforms lcsh:Veterinary medicine E. coli STa STb Stx2 F4 F18 Streptococcus Chemistry Research Microbiota 0402 animal and dairy science 04 agricultural and veterinary sciences 040201 dairy & animal science Diet Diarrhea 030104 developmental biology F4 lcsh:SF600-1100 Animal Science and Zoology lcsh:Animal culture medicine.symptom Weight gain Stx2 Food Science Biotechnology |
| Zdroj: | Journal of Animal Science and Biotechnology, Vol 11, Iss 1, Pp 1-16 (2020) Journal of Animal Science and Biotechnology Journal of Animal Science and Biotechnology. 2020, vol. 11, issue 1, p. 1-16. |
| ISSN: | 1674-9782 |
| Popis: | Background The high doses of zinc oxide (ZnO) administered orally to piglets for the prevention of diarrhea and increase of growth rate can contaminate pig farms and the surrounding environment. Therefore, there is a need to find a replacement of high doses of dietary ZnO with an equally effective alternative. In the present study, the effect of two formulations of zinc phosphate-based nanoparticles (ZnA and ZnC NPs) on growth performance, intestinal microbiota, antioxidant status, and intestinal and liver morphology was evaluated. A total of 100 weaned piglets were randomly divided into 10 equal groups with the base diet (control) or the base diet supplemented with ZnA, ZnC, or ZnO at concentrations 500, 1000, and 2000 mg Zn per kilogram of diet. Supplements were given to animals for 10 days. Fecal samples were collected on day 0, 5, 10 and 20. At the end of the treatment (day 10), three piglets from each group were sacrificed and analyzed. Results Comparing to that of control, the significantly higher piglet weight gain was observed in all piglet groups fed with ZnA (P P Escherichia (28.57–47.62%), Enterococcus (3.85–35.71%), and Streptococcus (3.70–42.31%) spp. A total of 542 Escherichia coli isolates were screened for the virulence genes STa, STb, Stx2, F4, and F18. The substantial occurrence of E. coli virulence factors was found on day 5, mainly in fimbrillary antigen and thermostable toxins, except for piglets fed by ZnC. Zn treatment decreased Zn blood levels in piglets fed with ZnO and ZnA (500 mg/kg) and increased in ZnC (2000 mg/kg) compared to that of control (P Conclusions Our results indicate that ZnA NPs have a positive effect on the piglet growth performance even at the lowest concentration. The prevalence of E. coli virulence factors was lowest in pigs supplemented with ZnC. Zinc phosphate-based nanoparticles may be an effective alternative to ZnO. |
| Databáze: | OpenAIRE |
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