CYP1A1 alleles in women with focal nodular hyperplasia of the liver (FNH)
| Autor: | Ivar Roots, Ingolf Cascorbi, Sachs M, S. Rietbrock, Lazar A, Kümel G, H. Menzel, Uwe Fuhr |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
medicine.medical_specialty Biology Polymerase Chain Reaction White People Internal medicine Germany medicine Cytochrome P-450 CYP1A1 Humans Pharmacology (medical) Allele Genotyping Allele frequency Alleles Pharmacology Polymorphism Genetic Focal nodular hyperplasia Odds ratio medicine.disease Endocrinology Focal Nodular Hyperplasia Women's Health Female Restriction fragment length polymorphism Steroid hormone metabolism Polymorphism Restriction Fragment Length Hormone |
| Zdroj: | International journal of clinical pharmacology and therapeutics. 42(2) |
| ISSN: | 0946-1965 |
| Popis: | Objective: Disorders of steroid hormone metabolism might be related to the etiology of focal nodular hyperplasia of the liver (FNH), a benign tumor, especially prevalent in women. The cytochrome P450 1AI (CYP1A1) enzyme is implicated in the bioactivation of multiple precarcinogens as well as in the metabolism of steroids. Genetic polymorphisms of CYP1A1 have been associated with altered catalytic activity in the hydroxylation of sex hormones and this may account for interindividual variability in exposure to hormone-mediated cell proliferation signals and reactive steroid metabolites. In the study at hand, we aimed to evaluate a possible association between CYP1A1*1, *2A, *2B, and *4 alleles and FNH. Method: Genotyping of 26 affected female patients of Caucasian origin was carried out using PCR/RFLP. Results: Allele frequencies for the CYP1A1 variants *2A, *2B and *4 in 26 female patients with FNH were 0.058, 0.019 and 0.058, respectively. Crude odds ratios for the individual alleles were 0.75 (95% Cl 0.23 - 2.44), 0.72 (95% CI 0.10 - 5.34) and 1.96 (95% CI 0.59 - 6.50), respectively. There were no significant differences between these values and corresponding allele frequencies obtained in a large German sample of unaffected Caucasian women. Conclusion: The present data do not suggest a relevant association between CYP1A1 polymorphisms and focal nodular hyperplasia of the liver in female Caucasians. |
| Databáze: | OpenAIRE |
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