CYP1B1 Polymorphisms and K-ras Mutations in Patients with Pancreatic Ductal Adenocarcinoma
| Autor: | José Pumarega, Marta Crous-Bou, Tomàs López, Núria Malats, Immaculata De Vivo, Francisco X. Real, Miquel Porta, Eva Morales, David J. Hunter, Joan Alguacil, Juli Rifà |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Pancreatic disease Genotype Physiology CYP1B1 Adenocarcinoma Biology Pancreatic cancer medicine Humans Neoplasm Prospective Studies Allele Gene Alleles Polymorphism Genetic Pancreatic Ducts Gastroenterology Cancer medicine.disease Pancreatic Neoplasms body regions Genes ras Logistic Models Spain Cytochrome P-450 CYP1B1 Mutation Cancer research Female Aryl Hydrocarbon Hydroxylases |
| Zdroj: | Digestive Diseases and Sciences. 53:1417-1421 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/s10620-008-0235-9 |
| Popis: | The frequency of CYP1B1 polymorphisms in pancreatic cancer has never been reported. There is also no evidence on the relationship between CYP1B1 variants and mutations in ras genes (K-, H- or N-ras) in any human neoplasm. We analyzed the following CYP1B1 polymorphisms in 129 incident cases of pancreatic ductal adenocarcinoma (PDA): the m1 allele (Val to Leu at codon 432) and the m2 allele (Asn to Ser at codon 453). The calculated frequencies for the m1 Val and m2 Asn alleles were 0.45 and 0.68, respectively. CYP1B1 genotypes were out of Hardy-Weinberg equilibrium; this was largely due to K-ras mutated PDA cases. The Val/Val genotype was over five times more frequent in PDA cases with a K-ras mutation than in wild-type cases (OR = 5.25; P = 0.121). In PDA, polymorphisms in CYP1B1 might be related with K-ras activation pathways. |
| Databáze: | OpenAIRE |
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