Infiltration of effector regulatory T cells predicts poor prognosis of diffuse large B-cell lymphoma, not otherwise specified
| Autor: | Kazuki Iwaki, Uta Nishiwaki, Mayumi Fujimoto, Shoko Nakayama, Taiji Yokote, Ayami Takayama, Yasuichiro Nishimura, Toshikazu Akioka, Motomu Tsuji, Takuji Miyoshi, Jun Hatooka, Nobuya Hiraoka, Yuki Masuda |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
education.field_of_study
Lymphoid Neoplasia Population FOXP3 hemic and immune systems chemical and pharmacologic phenomena Hematology Biology medicine.disease Lymphoma 03 medical and health sciences 0302 clinical medicine International Prognostic Index Antigen Tumor progression 030220 oncology & carcinogenesis mental disorders Immunology medicine Cytotoxic T cell education Diffuse large B-cell lymphoma psychological phenomena and processes 030215 immunology |
| Zdroj: | Blood Advances. 1:486-493 |
| ISSN: | 2473-9537 2473-9529 |
| Popis: | Regulatory T cells (Tregs) specifically express the transcription factor forkhead box P3 (FOXP3) and contribute to tumor progression. FOXP3-positive cells have been recently proven to be heterogeneous in phenotype and function, including effector Tregs (eTregs), naive Tregs, and non-Tregs, which harbor no suppressive function. Therefore, it is crucial to investigate the “true Treg (eTreg)” population, rather than the entire FOXP3 population, with regards to their effect on tumor immunity. In particular, in diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), FOXP3-positive cells correlated with a better prognosis. The present study sought to evaluate the relationship between the prognosis of DLBCL, NOS patients and the infiltration of true Tregs by employing dual immunostaining with FOXP3 and cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4). CTLA-4 is a negative immunomodulatory known to be expressed by eTregs, but not by non-Tregs. Lymph nodes from 82 nodal DLBCL, NOS patients were stained with anti-FOXP3 and anti–CTLA-4 antibodies. A high infiltration of FOXP3-positive cells was associated with a significantly better prognosis than patients with low levels of FOXP3-positive cells for overall survival (OS) ( P = .0233). In sharp contrast, a high infiltration of FOXP3/CTLA-4 double-positive cells was significantly associated with a poor prognosis than patients with low levels of FOXP3/CTLA-4 double-positive cells for OS ( P = .0121) and progression-free survival ( P = .0171), independent of the international prognostic index. FOXP3/CTLA-4 double-positive cells, eTregs, play an important role in DLBCL, NOS progression. |
| Databáze: | OpenAIRE |
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