Prevalence of dengue antibodies in healthy children and adults in different Colombian endemic areas
| Autor: | Myriam L. Velandia-Romero, Carolina Coronel-Ruiz, Víctor Alberto Olano, Angélica Castellanos, Myriam Arévalo-Herrera, María Angélica Calderón-Peláez, Sigrid Camacho-Ortega, Wilmer E. Villamil-Gómez, Lorena Castro-Bonilla, Jaime E. Castellanos, Alexandra Porras |
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| Přispěvatelé: | Castellanos, Jaime [0000-0003-1596-8383], Olano, Víctor Alberto [0000-0003-4010-0973], Velandia-Romero, Myriam Lucía [0000-0002-3340-7304], Porras-Ramírez, Alexandra [0000-0002-0800-1388], Coronel-Ruiz, Carolina [0000-0003-2202-5682], Camacho Ortega, Sigrid Johanna [0000-0002-3145-4748], Corolnel-Ruíz, Carolina [0000-0003-2202-5682] |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Serotype Male Endemic Diseases Estudios transversales Seroprevalence Dengue virus medicine.disease_cause Antibodies Viral Serology Dengue fever Dengue 0302 clinical medicine Seroepidemiologic Studies Dengue asymptomatic 030212 general & internal medicine Child Aged 80 and over education.field_of_study biology Coinfection General Medicine Middle Aged Infectious Diseases Child Preschool Dengue symptomatic RNA Viral Female Antibody Microbiology (medical) Adult Anticuerpos Adolescent 030106 microbiology Population Colombia Serogroup lcsh:Infectious and parasitic diseases 03 medical and health sciences Young Adult medicine Humans lcsh:RC109-216 education Infecciones por flavivirus Aged business.industry Dengue Virus medicine.disease Immunoglobulin M Immunoglobulin G Immunology biology.protein Rural area business |
| Zdroj: | Repositorio U. El Bosque Universidad El Bosque instacron:Universidad El Bosque International Journal of Infectious Diseases, Vol 91, Iss, Pp 9-16 (2020) |
| Popis: | Objectives: Colombia is a dengue hyperendemic country; however, the prevalence of antibodies against dengue in the general population including the inhabitants of rural areas is unknown. This study aimed to determine the prevalence of dengue IgM and IgG antibodies in healthy children and adults in urban and rural areas of seven different endemic regions in Colombia between 2013 and 2015. Design or method: Blood samples from healthy volunteers (1,318) were processed by serology (by indirect IgG and capture IgM and IgG ELISA) and molecular tests to detect viral RNA and circulating serotypes. Results: The seroprevalence of IgG for dengue were 85% in children and over 90% for adults. In addition to the high IgM positive rate (14.9%) and secondary recent infection marker rate (capture IgG, 16%), 8.4% of the healthy volunteers were positive for dengue virus (DENV) RNA. Conclusion: This study confirmed the broad and permanent circulation of DENV in Colombia and the high rates of infection and reinfection suffered by its inhabitants. This information can be used by the health authorities to strengthen vector control and vaccine policies and review the algorithms of diagnosis and disease management in children and adults. Keywords: Seroprevalence, Dengue symptomatic, Dengue asymptomatic, Colombia |
| Databáze: | OpenAIRE |
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