Unknown primary head and neck squamous cell carcinoma in the era of fluorodeoxyglucose-positron emission tomography/CT and intensity-modulated radiotherapy
Autor: | Abrahim Al-Mamgani, Michiel W. M. van den Brekel, Mischa de Ridder, Jan-Paul de Boer, Olga Hamming-Vrieze, Martin Klop, Bas Jasperse, Wouter V. Vogel, Laura A. Smit |
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Přispěvatelé: | Radiology and nuclear medicine, Amsterdam Gastroenterology Endocrinology Metabolism, MKA AMC (OII, ACTA), AIHR (FGw), ACTA, Maxillofacial Surgery (AMC), Academic Centre for Dentistry Amsterdam, Radiotherapy, Graduate School, CCA - Imaging and biomarkers, Oral and Maxillofacial Surgery |
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Oncology
Male medicine.medical_specialty medicine.medical_treatment Risk Assessment Disease-Free Survival 030218 nuclear medicine & medical imaging Metastasis Fluorodeoxyglucose positron emission tomography Cohort Studies 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Fluorodeoxyglucose F18 Internal medicine Positron Emission Tomography Computed Tomography Medicine Humans Aged Netherlands Proportional Hazards Models Retrospective Studies Analysis of Variance business.industry Head and neck cancer Cancer Middle Aged medicine.disease Prognosis Head and neck squamous-cell carcinoma Survival Analysis Radiation therapy Treatment Outcome Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Unknown primary Carcinoma Squamous Cell Neoplasms Unknown Primary Female Radiology Lymph Radiotherapy Intensity-Modulated business |
Zdroj: | Head & Neck, 39(7), 1382-1391. Wiley Subscription Services, Inc., A Wiley Company Hoboken Head & Neck, 39(7), 1382-1391. John Wiley and Sons Inc. de Ridder, M, Klop, M, Hamming-Vrieze, O, de Boer, J P, Jasperse, B, Smit, L, Vogel, W, van den Brekel, M & Al-Mamgani, A 2017, ' Unknown primary head and neck squamous cell carcinoma in the era of fluorodeoxyglucose-positron emission tomography/CT and intensity-modulated radiotherapy ', Head and Neck, vol. 39, no. 7, pp. 1382-1391 . https://doi.org/10.1002/hed.24762 Head and Neck, 39(7), 1382-1391. John Wiley and Sons Inc. Head & neck, 39(7), 1382-1391. John Wiley and Sons Inc. |
ISSN: | 1043-3074 |
Popis: | BackgroundThe diagnosis and treatment of head and neck carcinoma of unknown primary (CUP) have changed with the introduction of fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT and intensity-modulated radiotherapy (IMRT), with potential implications for outcome.MethodsWe conducted a retrospective analysis of 80 patients with head and neck CUP who were PET-staged and treated with curative intention using IMRT between 2006 and 2016 in the Netherlands Cancer Institute. Patient, tumor, and treatment demographics were recorded and oncologic outcomes were analyzed.ResultsLocal control was 100% in mucosal irradiated patients. Regional control was 90%. Ten patients developed distant metastases, which were associated with N3, extracapsular extension (ECE) and lower neck positive lymph nodes. Overall survival (OS) at 5 years was 62% and disease-specific survival was 78%. ECE, N3 neck, multiple levels of positive lymph nodes, and positive lymph nodes in the lower neck were associated with worse prognosis.ConclusionLocoregional outcome of head and neck CUP managed with modern techniques is good. Future research needs to focus on reducing toxicity and patients prone for distant metastasis. |
Databáze: | OpenAIRE |
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