Unknown primary head and neck squamous cell carcinoma in the era of fluorodeoxyglucose-positron emission tomography/CT and intensity-modulated radiotherapy

Autor: Abrahim Al-Mamgani, Michiel W. M. van den Brekel, Mischa de Ridder, Jan-Paul de Boer, Olga Hamming-Vrieze, Martin Klop, Bas Jasperse, Wouter V. Vogel, Laura A. Smit
Přispěvatelé: Radiology and nuclear medicine, Amsterdam Gastroenterology Endocrinology Metabolism, MKA AMC (OII, ACTA), AIHR (FGw), ACTA, Maxillofacial Surgery (AMC), Academic Centre for Dentistry Amsterdam, Radiotherapy, Graduate School, CCA - Imaging and biomarkers, Oral and Maxillofacial Surgery
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Oncology
Male
medicine.medical_specialty
medicine.medical_treatment
Risk Assessment
Disease-Free Survival
030218 nuclear medicine & medical imaging
Metastasis
Fluorodeoxyglucose positron emission tomography
Cohort Studies
03 medical and health sciences
0302 clinical medicine
SDG 3 - Good Health and Well-being
Fluorodeoxyglucose F18
Internal medicine
Positron Emission Tomography Computed Tomography
Medicine
Humans
Aged
Netherlands
Proportional Hazards Models
Retrospective Studies
Analysis of Variance
business.industry
Head and neck cancer
Cancer
Middle Aged
medicine.disease
Prognosis
Head and neck squamous-cell carcinoma
Survival Analysis
Radiation therapy
Treatment Outcome
Otorhinolaryngology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Unknown primary
Carcinoma
Squamous Cell
Neoplasms
Unknown Primary
Female
Radiology
Lymph
Radiotherapy
Intensity-Modulated
business
Zdroj: Head & Neck, 39(7), 1382-1391. Wiley Subscription Services, Inc., A Wiley Company Hoboken
Head & Neck, 39(7), 1382-1391. John Wiley and Sons Inc.
de Ridder, M, Klop, M, Hamming-Vrieze, O, de Boer, J P, Jasperse, B, Smit, L, Vogel, W, van den Brekel, M & Al-Mamgani, A 2017, ' Unknown primary head and neck squamous cell carcinoma in the era of fluorodeoxyglucose-positron emission tomography/CT and intensity-modulated radiotherapy ', Head and Neck, vol. 39, no. 7, pp. 1382-1391 . https://doi.org/10.1002/hed.24762
Head and Neck, 39(7), 1382-1391. John Wiley and Sons Inc.
Head & neck, 39(7), 1382-1391. John Wiley and Sons Inc.
ISSN: 1043-3074
Popis: BackgroundThe diagnosis and treatment of head and neck carcinoma of unknown primary (CUP) have changed with the introduction of fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT and intensity-modulated radiotherapy (IMRT), with potential implications for outcome.MethodsWe conducted a retrospective analysis of 80 patients with head and neck CUP who were PET-staged and treated with curative intention using IMRT between 2006 and 2016 in the Netherlands Cancer Institute. Patient, tumor, and treatment demographics were recorded and oncologic outcomes were analyzed.ResultsLocal control was 100% in mucosal irradiated patients. Regional control was 90%. Ten patients developed distant metastases, which were associated with N3, extracapsular extension (ECE) and lower neck positive lymph nodes. Overall survival (OS) at 5 years was 62% and disease-specific survival was 78%. ECE, N3 neck, multiple levels of positive lymph nodes, and positive lymph nodes in the lower neck were associated with worse prognosis.ConclusionLocoregional outcome of head and neck CUP managed with modern techniques is good. Future research needs to focus on reducing toxicity and patients prone for distant metastasis.
Databáze: OpenAIRE
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