Polyostotic Fibrous Dysplasia Mimicking Bone Involvement in Hodgkin Lymphoma: A Pediatric Case and Literature Review
| Autor: | Anna Maria Testi, Fiorina Giona, Alessandro Corsi, A. Turchetti, Maria Luisa Moleti, L. Celli, Miriam D'Avanzo, Anna Zambrano, Mauro Celli, Gianfranco Lapietra |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test business.industry Fibrous dysplasia Dacarbazine Bone involvement Hodgkin lymphoma Hematology General Medicine medicine.disease Bleomycin Vinblastine chemistry.chemical_compound ABVD chemistry Biopsy medicine Differential diagnosis Polyostotic fibrous dysplasia business medicine.drug |
| Popis: | Bone involvement in Hodgkin lymphoma (HL) is rare. The differential diagnosis between HL bone localization and other malignant or benign skeletal diseases is challenging. We report the case of a girl affected by classic HL, initially staged IVA because of supradiaphragmatic lymph nodes and skeletal involvement. After 6 ABVD (adriamycin, bleomycin, vinblastine, dacarbazine) cycles, positron emission tomography (PET) showed a complete metabolic response of the nodal localizations and a persistent, high metabolic activity of bone lesions. Salvage treatment followed by autologous stem cell transplant was carried out. After the transplant, the bone lesions maintained a high metabolic activity at PET. A targeted bone biopsy led to the diagnosis of a fibrous dysplasia excluding the presence of HL. To our knowledge, the concomitant presence of HL and fibrous dysplasia has not been previously reported. An in-depth evaluation of disease response to frontline treatment with a biopsy of the PET-hypercaptant bone lesions could have avoided overtreatment in this patient. |
| Databáze: | OpenAIRE |
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