Use of refractometry and colorimetry as field methods to rapidly assess antimalarial drug quality
| Autor: | Henry Nettey, Chansapha Pamanivong, Facundo M. Fernández, Michael D. Green, Lamphet Khounsaknalath, Paul N. Newton, Latsamy Vongsack, Ofelia Villalva Rojas, Miguel Grande Ortiz, Ot Manolin |
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| Rok vydání: | 2007 |
| Předmět: |
Quality Control
Drug Sulfadoxine medicine.medical_treatment media_common.quotation_subject Clinical Biochemistry Artesunate Pharmaceutical Science Pharmacology Analytical Chemistry Antimalarials chemistry.chemical_compound Chloroquine Drug Discovery medicine Colorimetry Chromatography High Pressure Liquid Spectroscopy media_common Quinine Traditional medicine Chemistry Reference Standards Artemisinins Drug quality Refractometry Indicators and Reagents Spectrophotometry Ultraviolet Sesquiterpenes medicine.drug |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 43:105-110 |
| ISSN: | 0731-7085 |
| Popis: | The proliferation of counterfeit and poor-quality drugs is a major public health problem; especially in developing countries lacking adequate resources to effectively monitor their prevalence. Simple and affordable field methods provide a practical means of rapidly monitoring drug quality in circumstances where more advanced techniques are not available. Therefore, we have evaluated refractometry, colorimetry and a technique combining both processes as simple and accurate field assays to rapidly test the quality of the commonly available antimalarial drugs; artesunate, chloroquine, quinine, and sulfadoxine. Method bias, sensitivity, specificity and accuracy relative to high-performance liquid chromatographic (HPLC) analysis of drugs collected in the Lao PDR were assessed for each technique. The HPLC method for each drug was evaluated in terms of assay variability and accuracy. The accuracy of the combined method ranged from 0.96 to 1.00 for artesunate tablets, chloroquine injectables, quinine capsules, and sulfadoxine tablets while the accuracy was 0.78 for enterically coated chloroquine tablets. These techniques provide a generally accurate, yet simple and affordable means to assess drug quality in resource-poor settings. |
| Databáze: | OpenAIRE |
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