The intracerebroventricularly administered mast cells degranulator compound 48/80 increases the pituitary-adrenocortical activity in rats
| Autor: | Chłap Z, A Gadek-Michalska, W. A. Fogel, Turoń M, Jan Bugajski |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Immunology Mepyramine Hypothalamus Cytoplasmic Granules Toxicology chemistry.chemical_compound Thalamus Corticosterone Internal medicine medicine Animals p-Methoxy-N-methylphenethylamine Pharmacology (medical) Mast Cells Cimetidine Pyrilamine Pharmacology Degranulation Histaminergic Brain Rats Inbred Strains Compound 48/80 Mast cell Rats Kinetics Endocrinology medicine.anatomical_structure chemistry Pituitary Gland Adrenal Cortex Histamine medicine.drug |
| Zdroj: | Agents and Actions. 32:203-208 |
| ISSN: | 1420-908X 0065-4299 |
| DOI: | 10.1007/bf01980874 |
| Popis: | The effect of brain mast cells degranulation by compound 48/80 on the pituitary-adrenocortical activity, measured indirectly through corticosterone secretion, and the involvement of a histaminergic mechanism in that stimulation was investigated in conscious rats. All the drugs were given intracerebroventricularly (icv), histamine antagonists 15 min prior to compound 48/80. Compound 48/80 induced a significant dose- and time-related increase in the serum corticosterone levels. That increase, measured 1 h after administration of compound 48/80, was moderately diminished by icv pretreatment of rats with mepyramine and cimetidine, histamine H1- and H2-receptor antagonists. Three hours after administration of compound 48/80 mast cells of the thalamus and the hypothalamus were completely degranulated. At the same time the thalamus and the whole brain histamine levels were substantially higher than in the saline-treated control rats. The above results suggest that histamine liberated from the brain mast cells and central histamine receptors play a moderate role in increasing the pituitary-adrenocortical activity by compound 48/80. |
| Databáze: | OpenAIRE |
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