Comparison of Initial Clinical Presentations between Primary Hyperparathyroidism Patients from New Brunswick and Changsha
| Autor: | Shuying Liu, Zhifeng Sheng, Lingqiong Meng, Aseel Al-Dayyeni, Zhiguang Zhou, Xiangbing Wang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Article Subject endocrine system diseases Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 030204 cardiovascular system & hematology lcsh:Diseases of the endocrine glands. Clinical endocrinology behavioral disciplines and activities Gastroenterology 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Parathyroid adenoma Bone mineral lcsh:RC648-665 Endocrine and Autonomic Systems business.industry Incidence (epidemiology) Retrospective cohort study medicine.disease University hospital Lumbar spine Kidney stones business Primary hyperparathyroidism Research Article |
| Zdroj: | International Journal of Endocrinology International Journal of Endocrinology, Vol 2018 (2018) |
| ISSN: | 1687-8345 1687-8337 |
| DOI: | 10.1155/2018/6282687 |
| Popis: | Purpose. To compare the initial clinical features, laboratory values, and bone mineral density among patients with primary hyperparathyroidism (PHPT) in Changsha (China) and New Brunswick (USA). Methods. In this retrospective study, we reviewed 169 PHPT patients who presented at Robert Wood Johnson University Hospital and 133 PHPT patients who presented at the Second Xiangya Hospital of Central South University in the same time period. The following characteristics were compared between the groups: age, gender, BMI, serum calcium, alkaline phosphatase (AKP), albumin, intact PTH (iPTH), 25-hydroxyvitamin D (25 (OH) D), fasting blood glucose levels, and bone mineral density (BMD). All these parameters were also compared according to gender and menopausal status. iPTH associations were also assessed along with several other parameters. Results. PHPT patients from Changsha had higher serum calcium, iPTH, and AKP levels but lower 25 (OH) D levels than the patients from New Brunswick (p<0.05). Patients in Changsha had lower T-scores and Z-scores in both the lumbar spine and hip regions than those in New Brunswick (p<0.05). Patients in New Brunswick had lower percentages of parathyroid adenoma and kidney stones. Serum iPTH level was positively correlated with serum calcium and serum AKP levels in both Changsha and New Brunswick (p<0.05). Conclusions. There are distinct biochemical and clinical differences between patients with PHPT in China and the United States. Our study revealed that Asian PHPT patients from Changsha presented more severe PHPT profiles, lower bone mineral density, and higher incidence of renal stones. |
| Databáze: | OpenAIRE |
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