Altered regional homogeneity in patients with diabetic vitreous hemorrhage
| Autor: | Qiong Zhou, Fei-Yin Zhu, Biao Li, Yi Shao, Pei-Wen Zhu, Wen-Qing Shi, Yu-Qing Zhang, Qi Lin, You-Lan Min, Li-Ying Tang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Visual acuity Brain activity and meditation Endocrinology Diabetes and Metabolism Functional magnetic resonance imaging Clinical Trials Study Diabetic vitreous hemorrhage 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Regional homogeneity 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Ophthalmology Internal Medicine medicine Resting state medicine.diagnostic_test Resting state fMRI business.industry Medial frontal gyrus medicine.anatomical_structure Visual cortex Superior frontal gyrus medicine.symptom business Complication |
| Zdroj: | World Journal of Diabetes |
| ISSN: | 1948-9358 |
| Popis: | Background Diabetic vitreous hemorrhage (DVH) is a common complication of diabetes. While the diagnostic methods nowadays only concentrate on the eye injury in DVH patients, whether DVH leads to abnormalities of other visual systems, including the eye, the visual cortex, and other brain regions, remains unknown. Aim To explore the potential changes of brain activity in DVH using regional homogeneity (ReHo) and their relationships with clinical features. Methods Thirty-one DVH patients and 31 matched healthy controls (HCs) were recruited. All subjects were examined by resting-state functional magnetic resonance imaging. The neural homogeneity in the brain region was estimated by ReHo method. Pearson correlation analysis was used to evaluate the relationships between average ReHo values and clinical manifestations in DVH patients. Results Compared with HCs, the ReHo values in the bilateral cerebellar posterior lobes, right superior (RS)/middle occipital gyrus (MOG), and bilateral superior frontal gyrus were significantly increased. In contrast, in the right insula, bilateral medial frontal gyri, and right middle frontal gyrus, the ReHo values were significantly decreased. Furthermore, we found that best-corrected visual acuity of the contralateral eye in patients with DVH presented a positive correlation with the mean ReHo value of the RS/MOG. We also found that depression score of the DVH group presented a negative correlation with the mean ReHo values of the right insula, bilateral medial frontal gyrus, and right middle frontal gyrus. Conclusion We found that DVH may cause dysfunction in multiple brain areas, which may benefit the exploration of pathologic mechanisms in DVH patients. |
| Databáze: | OpenAIRE |
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