Synthesis and antitumor activity of new dihydropyridine thioglycosides and their corresponding dehydrogenated forms
| Autor: | Nahed M. Fathy, Hebat-Allah S. Abbas, Wael A. El Sayed |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Dihydropyridines Nitrile Stereochemistry Antineoplastic Agents Chemical synthesis Mice chemistry.chemical_compound Bromide Cell Line Tumor Neoplasms Drug Discovery Pyridine medicine Animals Humans Dehydrogenation Cytotoxicity Pharmacology Molecular Structure Chemistry Organic Chemistry Dihydropyridine General Medicine In vitro Thioglycosides Hydrogenation Drug Screening Assays Antitumor medicine.drug |
| Zdroj: | European Journal of Medicinal Chemistry. 45:973-982 |
| ISSN: | 0223-5234 |
| Popis: | A number of a new pyridine thioglycosides were synthesized via reaction of piperidinium salts of dihydropyridinethiones with 2,3,4,6-tetra- O -acetyl-α- d -gluco- and galactopyranosyl bromide. The antitumor activities of the synthesized compounds were evaluated utilizing two different human cell lines. Some of the tested compounds showed high inhibition of human cell lines. The detailed synthesis, spectroscopic data and antitumor activities for the synthesized compounds were reported. |
| Databáze: | OpenAIRE |
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