Asymptomatic memory CD8+ T cells: From development and regulation to consideration for human vaccines and immunotherapeutics
| Autor: | Patricia P. Lopes, Lucas Gutierrez, Justin Cochrane, Thanh T. Pham, Christine Wang, Lbachir BenMohamed, Arif A. Khan, Ruchi Srivastava, Nhi Thi Uyen Thai |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
methods [Immunotherapy]
T cell immunology [T-Lymphocyte Subsets] Immunology Disease Review Herpesvirus Vaccines Biology CD8-Positive T-Lymphocytes medicine.disease_cause Asymptomatic Ocular herpes Epitope T-Lymphocyte Subsets medicine Medicine and Health Sciences Immunology and Allergy Cytotoxic T cell Humans Pharmacology immunology [CD8-Positive T-Lymphocytes] medicine.disease Virology Herpes simplex virus medicine.anatomical_structure immunology [Herpesvirus Vaccines] Immunotherapy medicine.symptom Immunologic Memory CD8 |
| Zdroj: | Khan, Arif Azam; Srivastava, Ruchi; Lopes, Patricia Prado; Wang, Christine; Pham, Thanh T; Cochrane, Justin; et al.(2014). Asymptomatic memory CD8+ T cells: from development and regulation to consideration for human vaccines and immunotherapeutics.. Human vaccines & immunotherapeutics, 10(4), 945-963. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/16q0g0br |
| Popis: | Generation and maintenance of high quantity and quality memory CD8(+) T cells determine the level of protection from viral, bacterial, and parasitic re-infections, and hence constitutes a primary goal for T cell epitope-based human vaccines and immunotherapeutics. Phenotypically and functionally characterizing memory CD8(+) T cells that provide protection against herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2) infections, which cause blinding ocular herpes, genital herpes, and oro-facial herpes, is critical for better vaccine design. We have recently categorized 2 new major sub-populations of memory symptomatic and asymptomatic CD8(+) T cells based on their phenotype, protective vs. pathogenic function, and anatomical locations. In this report we are discussing a new direction in developing T cell-based human herpes vaccines and immunotherapeutics based on the emerging new concept of "symptomatic and asymptomatic memory CD8(+) T cells." |
| Databáze: | OpenAIRE |
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