Unexpectedly Enhanced Solubility of Aromatic Amino Acids and Peptides in an Aqueous Solution of Divalent Transition-Metal Cations
| Autor: | Tingting Pan, Shaoxian Li, Lijuan Zhang, Shaoping Li, Haiping Fang, Guosheng Shi, Ya-Ru Dang, Jichen Li, Dehong Yu, Hongwei Zhao, Xing Liu, Jiaguang Han, Yiming Zhu, Qing Ji, Renzhong Tai, Richard A. Mole, Hui Liu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
inorganic chemicals
Cations Divalent Phenylalanine General Physics and Astronomy 02 engineering and technology 010402 general chemistry Ring (chemistry) 01 natural sciences Medicinal chemistry Divalent chemistry.chemical_compound Transition metal Cations Aromatic amino acids Transition Elements Solubility Amino Acids chemistry.chemical_classification Aqueous solution Chemistry Tryptophan Dipeptides 021001 nanoscience & nanotechnology 0104 chemical sciences Metals 0210 nano-technology Peptides |
| Zdroj: | Physical review letters. 117(23) |
| ISSN: | 1079-7114 |
| Popis: | We experimentally observed considerable solubility of tryptophan (Trp) in a CuCl_{2} aqueous solution, which could reach 2-5 times the solubility of Trp in pure water. Theoretical studies show that the strong cation-π interaction between Cu^{2+} and the aromatic ring in Trp modifies the electronic distribution of the aromatic ring to enhance significantly the water affinity of Trp. Similar solubility enhancement has also been observed for other divalent transition-metal cations (e.g., Zn^{2+} and Ni^{2+}), another aromatic amino acid (phenylalanine), and three aromatic peptides (Trp-Phe, Phe-Phe, and Trp-Ala-Phe). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|