nm23-H1 protein expression in anal canal carcinoma: Does it correlate with prognosis?
| Autor: | M. R. Limiti, Marileda Indinnimeo, C Ghini, Cicchini C, Stazi A, Enrico Giarnieri, Aldo Vecchione |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Pathology medicine.medical_specialty Mitomycin Cellular differentiation nm23 medicine.disease_cause Drug Administration Schedule Antineoplastic Combined Chemotherapy Protocols Gene expression medicine Carcinoma Humans Clinical significance anal neoplasms immunohistochemistry monoclonal antibody prognosis Aged Monomeric GTP-Binding Proteins business.industry Antibodies Monoclonal General Medicine Middle Aged NM23 Nucleoside Diphosphate Kinases Anal canal Anus Neoplasms Prognosis medicine.disease Combined Modality Therapy Immunohistochemistry Treatment Outcome medicine.anatomical_structure Oncology Nucleoside-Diphosphate Kinase Female Surgery Fluorouracil Carcinogenesis business Immunostaining Transcription Factors |
| Zdroj: | Journal of Surgical Oncology. 74:163-166 |
| ISSN: | 1096-9098 0022-4790 |
| DOI: | 10.1002/1096-9098(200006)74:2<163::aid-jso16>3.0.co;2-d |
| Popis: | Background and Objectives Anatomic extent is not the sole axis of classification of tumors and of tumor patients relevant to treatment planning and estimation of prognosis. This results in the need to demonstrate an improvement in prognostic assessment and choice of therapy achieved by consideration of factors other than TNM. nm23 protein does prevent tumor from metastasizing and may also play a role in the control of growth and development. The purpose of this study was to elucidate the clinical significance of nm23 expression in human anal canal carcinoma and to evaluate its influence on the outcome of patients after surgery or radiochemotherapy. Methods Twenty-two patients affected by anal canal carcinoma were evaluated. Each section was incubated with monoclonal antibody nm23 NDPK-A. Immunostaining was considered positive when at least 10% of the tumor cells were immunostained. Results nm23 immunoreactivity was detected in 6/22 (27.3%) tumors. No significant association was found between nm23 expression and prognosis. Conclusions The mechanisms causing enhanced nm23-H1 expression in anal canal carcinoma are unknown. Although the level and expression were not correlated with prognosis, activation of nm23-H1 gene might be a prerequisite for oncogenesis in this type of tumor, while an alternate possibility is the modification of cellular characteristics in relation to proliferation and/or differentiation as a consequence of oncogenesis. J. Surg. Oncol. 2000;74:163–166. © 2000 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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