Cruising the cellular highways: how human papillomavirus travels from the surface to the nucleus
Autor: | Martin Sapp, Malgorzata Bienkowska-Haba, Lucile G. M. Guion, Stephen DiGiuseppe |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Cancer Research Retromer Nuclear Envelope media_common.quotation_subject Mitosis Virus Attachment Promyelocytic Leukemia Protein Endocytosis Genome Article 03 medical and health sciences Promyelocytic leukemia protein Transcription (biology) Virology Virus Uncoating Humans Internalization Papillomaviridae media_common Skin biology Papillomavirus Infections Virion virus diseases Epithelial Cells Virus Internalization Cell biology 030104 developmental biology Infectious Diseases Capsid Gene Expression Regulation Host-Pathogen Interactions biology.protein Capsid Proteins trans-Golgi Network |
Popis: | The non-enveloped human papillomaviruses (HPVs) specifically target epithelial cells of the skin and mucosa. Successful infection requires a lesion in the stratified tissue for access to the basal cells. Herein, we discuss our recent progress in understanding binding, internalization, uncoating, and intracellular trafficking of HPV particles. Our focus will be on HPV type 16, which is the most common HPV type associated with various anogenital and oropharyngeal carcinomas. The study of HPV entry has revealed a number of novel cellular pathways utilized during infection. These include but are not restricted to the following: a previously uncharacterized form of endocytosis, membrane penetration by a capsid protein, the use of retromer complexes for trafficking to the trans-Golgi network, the requirement for nuclear envelope breakdown and microtubule-mediated transport during mitosis for nuclear entry, the existence of membrane-bound intranuclear vesicles harboring HPV genome, and the requirement of PML protein for efficient transcription of incoming viral genome. The continued study of these pathways may reveal new roles in basic biological cellular processes. |
Databáze: | OpenAIRE |
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