Intraoperative haloperidol does not improve quality of recovery and postoperative analgesia
| Autor: | Masood Mohseni, Mojtaba Akbari, Amin Ebneshahidi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Nausea Sedation Analgesic lcsh:Medicine law.invention Randomized controlled trial law quality of recovery Haloperidol medicine pain lcsh:QH301-705.5 business.industry lcsh:R General Medicine nausea randomized clinical trial Surgery lcsh:Biology (General) Anesthesia Orthopedic surgery Morphine Vomiting Original Article medicine.symptom business medicine.drug |
| Zdroj: | Advanced Biomedical Research Advanced Biomedical Research, Vol 2, Iss 1, Pp 85-85 (2013) |
| ISSN: | 2277-9175 |
| Popis: | Introduction: Haloperidol has an established role in nausea and vomiting prophylaxis and possible effects on multiple aspects of postoperative recovery including pain and sedation. The purpose of this study was to evaluate the effects of low-dose intraoperative intravenous haloperidol on quality of recovery (QoR) and pain control after general anesthesia and surgery. Methods: Ninety eight American Society of Anesthesiologists (ASA) physical status I-II patients undergoing elective general, gynecologic or orthopedic surgery under general anesthesia were enrolled. Participants were randomly allocated to receive either haloperidol 2 mg or sterile water intravenously after induction of anesthesia. All patients were given elastometric morphine patient-controlled analgesia (PCA) pump for pain control after the surgery. Post-operative QoR was evaluated within 20 min in the recovery room and 6 h post-operatively. Pain intensity and demand for additional analgesic was measured in the 6 th post-operative hour. Results: The QoR score in two measurements was not statistically different between the two groups. Haloperidol significantly reduced the nausea in the recovery. The visual analog scale pain score showed that the severity of pain in the haloperidol group was more than the placebo group (4.7 ± 2.4 vs. 3.8 ± 2.5, P = 0.05). Conclusion: Intraoperative small-dose IV haloperidol is effective against post-operative nausea and vomiting with no significant effect on overall QoR. It may also attenuate the analgesic effects of morphine PCA. |
| Databáze: | OpenAIRE |
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