Water as a Blood Model for Determination of CO2 Removal Performance of Membrane Oxygenators
| Autor: | Margit Gfoehler, Bahram Haddadi, Paul Ecker, Raffael Koller, Martin Elenkov, Markus Pekovits, Michael Harasek, Christian Jordan, Christoph Janeczek, Benjamin Lukitsch |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
in vivo tests
Materials science Oxygenators 010504 meteorology & atmospheric sciences Membrane oxygenators oxygenator development 0206 medical engineering Filtration and Separation 02 engineering and technology TP1-1185 01 natural sciences In vivo tests Article carbon dioxide (CO2) removal Chemical engineering Co2 removal Chemical Engineering (miscellaneous) membrane oxygenation 0105 earth and related environmental sciences Process Chemistry and Technology Chemical technology 020601 biomedical engineering membrane modeling Boundary layer in vitro tests TP155-156 Porcine blood computational fluid dynamic simulations Biomedical engineering |
| Zdroj: | Membranes Volume 11 Issue 5 Membranes, Vol 11, Iss 356, p 356 (2021) |
| ISSN: | 2077-0375 |
| DOI: | 10.3390/membranes11050356 |
| Popis: | CO2 removal via membrane oxygenators has become an important and reliable clinical technique. Nevertheless, oxygenators must be further optimized to increase CO2 removal performance and to reduce severe side effects. Here, in vitro tests with water can significantly reduce costs and effort during development. However, they must be able to reasonably represent the CO2 removal performance observed with blood. In this study, the deviation between the CO2 removal rate determined in vivo with porcine blood from that determined in vitro with water is quantified. The magnitude of this deviation (approx. 10%) is consistent with results reported in the literature. To better understand the remaining difference in CO2 removal rate and in order to assess the application limits of in vitro water tests, CFD simulations were conducted. They allow to quantify and investigate the influences of the differing fluid properties of blood and water on the CO2 removal rate. The CFD results indicate that the main CO2 transport resistance, the diffusional boundary layer, behaves generally differently in blood and water. Hence, studies of the CO2 boundary layer should be preferably conducted with blood. In contrast, water tests can be considered suitable for reliable determination of the total CO2 removal performance of oxygenators. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|