Nutritional screening based on objective indices at admission predicts in-hospital mortality in patients with COVID-19

Autor: Shouhong Wang, Qing Zhang, Hui-Qing Yuan, Xiuchan Song, Huan Ma, Qing Xu, Fei Li, Xiaoping Tan, Liao Youwan, Daozheng Huang, Zhong-Hua Wang, Tiehe Qin, Feier Song
Rok vydání: 2020
Předmět:
Male
Medicine (miscellaneous)
Comorbidity
010501 environmental sciences
Logistic regression
01 natural sciences
Severity of Illness Index
0302 clinical medicine
Risk Factors
TX341-641
030212 general & internal medicine
Hospital Mortality
Nutritional diseases. Deficiency diseases
education.field_of_study
Nutrition and Dietetics
Middle Aged
Thorax
Prognosis
Female
Adult
medicine.medical_specialty
China
RC620-627
Critical Illness
Population
Nutritional Status
Clinical nutrition
03 medical and health sciences
Internal medicine
Severity of illness
medicine
Humans
Mortality
education
0105 earth and related environmental sciences
Aged
Retrospective Studies
Nutrition
Nutrition. Foods and food supply
business.industry
SARS-CoV-2
Research
Malnutrition
COVID-19
Retrospective cohort study
medicine.disease
Coronavirus
Nutrition Assessment
Observational study
business
Tomography
X-Ray Computed
Zdroj: Nutrition Journal
Nutrition Journal, Vol 20, Iss 1, Pp 1-11 (2021)
ISSN: 1475-2891
Popis: Background Could nutritional status serve as prognostic factors for coronavirus disease 2019 (COVID-19)? The present study evaluated the clinical and nutritional characteristics of COVID-19 patients and explored the relationship between risk for malnutrition at admission and in-hospital mortality. Methods A retrospective, observational study was conducted in two hospitals in Hubei, China. Confirmed cases of COVID-19 were typed as mild/moderate, severe, or critically ill. Clinical data and in-hospital death were collected. The risk for malnutrition was assessed using the geriatric nutritional risk index (GNRI), the prognostic nutritional index (PNI), and the Controlling Nutritional Status (CONUT) via objective parameters at admission. Results Two hundred ninety-five patients were enrolled, including 66 severe patients and 41 critically ill patients. Twenty-five deaths were observed, making 8.47% in the whole population and 37.88% in the critically ill subgroup. Patients had significant differences in nutrition-related parameters and inflammatory biomarkers among three types of disease severity. Patients with lower GNRI and PNI, as well as higher CONUT scores, had a higher risk of in-hospital mortality. The receiver operating characteristic curves demonstrated the good prognostic implication of GNRI and CONUT score. The multivariate logistic regression showed that baseline nutritional status, assessed by GNRI, PNI, or CONUT score, was a prognostic indicator for in-hospital mortality. Conclusions Despite variant screening tools, poor nutritional status was associated with in-hospital death in patients infected with COVID-19. This study highlighted the importance of nutritional screening at admission and the new insight of nutritional monitoring or therapy.
Databáze: OpenAIRE
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