Defining a role of NADPH oxidase in myogenic tone development

Autor:	Galina Yu. Mironova, Neil Mazumdar, Ahmed M. Hashad, Mohammed A. El‐Lakany, Donald G. Welsh
Rok vydání:	2022
Předmět:	Physiology Physiology (medical) Myography Animals NADPH Oxidases Cerebral Arteries Cardiology and Cardiovascular Medicine Reactive Oxygen Species Molecular Biology Muscle Smooth Vascular Rats
Zdroj:	Microcirculation (New York, N.Y. : 1994)REFERENCES. 29(3)
ISSN:	1549-8719
Popis:	The myogenic response sets the foundation for blood flow control. Recent findings suggest a role for G protein-coupled receptors (GPCR) and signaling pathways tied to the generation of reactive oxygen species (ROS). In this regard, this study ascertained the impact of NADPH oxidase (Nox) on myogenic tone in rat cerebral resistance arteries.The study employed real-time qPCR (RT-qPCR), pressure myography, and immunohistochemistry.GOur data highlight that vascular pressurization augments Nox1 activity and ensuing ROS production facilitates myogenic tone by limiting Ca
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4453697284e4f277704fb83697d82cd4 https://pubmed.ncbi.nlm.nih.gov/35289024 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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