Comparative Cancer Cell Signaling in Muscle-Invasive Urothelial Carcinoma of the Bladder in Dogs and Humans

Autor: Thomas M. Steele, Maria Mudryj, Maria Malvina Tsamouri, Paramita M. Ghosh, Michael S. Kent
Rok vydání: 2021
Předmět:
Zdroj: Biomedicines, vol 9, iss 10
Biomedicines
Biomedicines, Vol 9, Iss 1472, p 1472 (2021)
Popis: Muscle-invasive urothelial carcinoma (MIUC) is the most common type of bladder malignancy in humans, but also in dogs that represent a naturally occurring model for this disease. Dogs are immunocompetent animals that share risk factors, pathophysiological features, clinical signs and response to chemotherapeutics with human cancer patients. This review summarizes the fundamental pathways for canine MIUC initiation, progression, and metastasis, emerging therapeutic targets and mechanisms of drug resistance, and proposes new opportunities for potential prognostic and diagnostic biomarkers and therapeutics. Identifying similarities and differences between cancer signaling in dogs and humans is of utmost importance for the efficient translation of in vitro research to successful clinical trials for both species.
Databáze: OpenAIRE