Comparative Cancer Cell Signaling in Muscle-Invasive Urothelial Carcinoma of the Bladder in Dogs and Humans
| Autor: | Thomas M. Steele, Maria Mudryj, Maria Malvina Tsamouri, Paramita M. Ghosh, Michael S. Kent |
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| Rok vydání: | 2021 |
| Předmět: |
Urologic Diseases
QH301-705.5 comparative oncology Medicine (miscellaneous) Review Disease Drug resistance Malignancy General Biochemistry Genetics and Molecular Biology Metastasis molecular cancer therapeutics medicine 2.1 Biological and endogenous factors naturally occurring models of cancer Biology (General) Aetiology urothelial carcinoma Cancer Bladder cancer business.industry medicine.disease Pathophysiology basic & translational cancer research Clinical trial Cancer cell Cancer research bladder cancer canine cancer business |
| Zdroj: | Biomedicines, vol 9, iss 10 Biomedicines Biomedicines, Vol 9, Iss 1472, p 1472 (2021) |
| Popis: | Muscle-invasive urothelial carcinoma (MIUC) is the most common type of bladder malignancy in humans, but also in dogs that represent a naturally occurring model for this disease. Dogs are immunocompetent animals that share risk factors, pathophysiological features, clinical signs and response to chemotherapeutics with human cancer patients. This review summarizes the fundamental pathways for canine MIUC initiation, progression, and metastasis, emerging therapeutic targets and mechanisms of drug resistance, and proposes new opportunities for potential prognostic and diagnostic biomarkers and therapeutics. Identifying similarities and differences between cancer signaling in dogs and humans is of utmost importance for the efficient translation of in vitro research to successful clinical trials for both species. |
| Databáze: | OpenAIRE |
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