Interrelationship between anticonvulsant and enzyme inhibitory properties of N-methyl-N-2-[1-(1-arylthiocarbamido)] cyclopentyl nitrobenzamides
| Autor: | Stanley J. Brumleve, Bhagwan R. Pandey, Shiva P. Singh, Surendra S. Parmar |
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| Rok vydání: | 1981 |
| Předmět: |
Pentobarbital
Monoamine Oxidase Inhibitors Time Factors Stereochemistry medicine.drug_class Monoamine oxidase Pyruvate Oxidase medicine.medical_treatment In Vitro Techniques Lethal Dose 50 chemistry.chemical_compound medicine Pyruvate oxidase Animals Enzyme Inhibitors Pharmacology Long-term potentiation Phenylthiourea In vitro Rats Anticonvulsant chemistry Anticonvulsants Depressant Pyruvic acid Sleep medicine.drug |
| Zdroj: | Pharmacological Research Communications. 13:65-74 |
| ISSN: | 0031-6989 |
| DOI: | 10.1016/s0031-6989(81)80039-2 |
| Popis: | A series of N-methyl-N-2-[1-(1-arylthiocarbamido)]cyclopentyl nitrobenzamides were synthesized and evaluated for their anticonvulsant activity and potentiation of pentobarbital-induced hypnosis. These compounds were also investigated for their ability to inhibit in vitro respiratory activity during oxidation of pyruvic acid and monoamine oxidase activity of rat brain homogenates. The results obtained from the above studies have failed to provide any structural correlationships between the central nervous system depressant and the enzyme inhibitory properties of these substituted nitrobenzamides. |
| Databáze: | OpenAIRE |
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