Fast and Green One-Pot Multicomponent Synthesis of a Library of Pyrrolo[1,2-c] Pyrimidines Under Microwave Irradiation
| Autor: | Marcel Mirel Popa, Florea Dumitrascu, E. I. Georgescu, Liliana Cristian, Constantin Draghici, Florentina Georgescu |
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| Rok vydání: | 2013 |
| Předmět: |
Magnetic Resonance Spectroscopy
Spectrophotometry Infrared Pyrimidine Organic Chemistry General Medicine Scavenger (chemistry) Computer Science Applications Solvent chemistry.chemical_compound Pyrimidines chemistry Cyclization Drug Discovery Microwave irradiation Organic chemistry Pyrroles Microwaves |
| Zdroj: | Combinatorial Chemistry & High Throughput Screening. 16:851-857 |
| ISSN: | 1386-2073 |
| DOI: | 10.2174/13862073113169990050 |
| Popis: | A simple, clean and rapid one-pot three component, microwave-assisted synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones and nonsymmetrical, electron deficient alkynes in 1,2-epoxybutane which acts both as solvent and acid scavenger is reported. This one-pot three component synthesis implies short reaction times being at the same time highly cost-effective and environmental friendly. |
| Databáze: | OpenAIRE |
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