Two new spongian diterpene derivatives from the aquaculture sponge Spongia officinalis Linnaeus, 1759

Autor:	Tianyun Jin, Huilong Ou, Lian-Zhong Luo, Xiaoli Yv, Guoqiang Li, Xuli Tang, Cili Wang, Ping-Lin Li, Kai Li
Rok vydání:	2021
Předmět:	biology Stereochemistry Chemistry business.industry Organic Chemistry Plant Science biology.organism_classification Biochemistry Terpenoid Analytical Chemistry chemistry.chemical_compound Sponge Aquaculture Diterpene business Spongia officinalis
Zdroj:	Natural Product Research. 37:216-226
ISSN:	1478-6427 1478-6419
DOI:	10.1080/14786419.2021.1961137
Popis:	2β,3α,19-Triacetoxy-17-hydroxyspongia-13(16),14-diene (1), a novel acetoxy diterpenoid, and 18-nor-2,17-hydroxyspongia-1,4,13(16),14-quaien-3-one (2), belonging to the rare 18-nor-spongian carbon skeleton, together with six related known metabolites (3‒8), were isolated from the aquaculture Spongia officinalis Linnaeus, 1759. Their structures were elucidated by comprehensive spectroscopic analysis, quantum chemical calculation of NMR parameters, and electronic circular dichroism (ECD). Compounds 3, 4, and 5 exhibited moderate inhibition against STAT3/NF-κB, HIF-1, Wnt signalling pathways. Compounds 1, 3, and 5 showed cytotoxicity activities against K562 cell line with IC50 values of 7.3, 3.5, and 6.4 μM, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444efd2799c0ee91909671d707d6d99c https://doi.org/10.1080/14786419.2021.1961137 Zobrazit plný text záznamu