Effects of GABA and L-glutamate on the gastric acid secretion and gastric defensive mechanisms in rat lateral hypothalamus
| Autor: | Masato Egawa, Yutaro Takamura, Shuji Inoue, Tsunehiro Namiki, Shizuo Tominaga |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Microinjections Physiology Glutamic Acid Biology Inhibitory postsynaptic potential Bicuculline GABA Antagonists Gastric Acid Rats Sprague-Dawley chemistry.chemical_compound Glutamates Internal medicine medicine Animals Picrotoxin Neurotransmitter gamma-Aminobutyric Acid Muscimol General Neuroscience digestive oral and skin physiology Stomach Glutamate receptor GABA receptor antagonist Rats Endocrinology chemistry Gastric Mucosa Regional Blood Flow Hypothalamic Area Lateral Excitatory postsynaptic potential GABAergic Gastric acid Female Neurology (clinical) |
| Zdroj: | Journal of the autonomic nervous system. 44(2-3) |
| ISSN: | 0165-1838 |
| Popis: | The effects of administration of an inhibitory GABAergic or excitatory glutaminergic neurotransmitter into the lateral hypothalamic area (LHA) on gastric acids, an aggressive mechanism, and transepithelial potential difference (PD) and mucosal blood flow (MBF), defensive mechanisms, were examined in anesthetized rats, since lesions of LHA in these animals cause gastric mucosal damage and electrical stimulation stimulates gastric acids and antral contractions. Microinfusion of the inhibitory neurotransmitter, muscimol (GABA agonist) resulted in an increase in gastric acid secretion and in PD and MBF. The GABA antagonists picrotoxin and bicuculline methiodide, in contrast, decreased these three factors. The excitatory neurotransmitter l -glutamate induced only an increase of MBF. Thus, the GABAergic system in LHA stimulates the gastric functions, both defensive and aggressive mechanisms, while the glutaminergic system increases only a portion of the defensive system. The results suggest that there is a significant interaction between LHA and stomach functions. |
| Databáze: | OpenAIRE |
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