A first insight into the genetic diversity of Mycobacterium Tuberculosis in Veracruz, Mexico
| Autor: | Javier Fuentes-Domínguez, Daniela Munro-Rojas, Alma Delia Guevara-Méndez, Raquel Almaraz-Velasco, Roberto Zenteno-Cuevas, Rosa Icela Chaparro-Martinez, Raquel Muñiz-Salazar, Maria Angélica Ibarra-Estela, Monserrat Perez-Navarro |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Genotyping medicine.medical_specialty Tuberculosis Cross-sectional study 030106 microbiology lcsh:QR1-502 lcsh:Microbiology Mycobacterium Mycobacterium tuberculosis 03 medical and health sciences Genotype Genetic variation Epidemiology medicine Mexico Genetic diversity biology mycobacterial interspersed repetitive unit-variable number tandem repeat biology.organism_classification medicine.disease 030104 developmental biology Infectious Diseases Demography |
| Zdroj: | International Journal of Mycobacteriology, Vol 6, Iss 1, Pp 14-20 (2017) |
| ISSN: | 2212-5531 |
| DOI: | 10.4103/2212-5531.201886 |
| Popis: | Objective/Background: Tuberculosis (TB) remains one of the most important infectious diseases. Although Mexico is one of the Latin American countries with the largest contribution to these statistics, there are few reports that describe the genotypic characteristics of TB. The aim of this study was to use the MIRU-VNTR-24 loci to analyze the genetic diversity of M. tuberculosis circulating in the state of Veracruz, Mexico. Methods: Here, we analyze by MIRU-VNTR-24 loci 80 clinical isolates from individuals with confirmed TB from Veracruz México, also clinical and epidemiological variables were recovered and analyzed. Results: Of the individuals included in the analyses 65% were from men with an average age of 42 (± 17) years, 17% and 6% were drug and multi-drug resistant. 88% of the isolates were included in 20 clusters, of which 52% were classified into twelve orphan clusters and the remaining 37% were distributed among eight lineages: LAM (10%), EAI (9%), Haarlem (8%), H37Rv (4%), S (4%) and TUR (2%). Conclusion: An important diversity of lineages and unknown genotypes was identified; however, more studies are necessary in order to understand the characteristics of the genotypes displayed in the region. There is no doubt regarding the need for a molecular epidemiological surveillance system that can help to evaluate the dynamics of genotypes circulating in the country and support strategies for the prevention and management of populations affected by TB. |
| Databáze: | OpenAIRE |
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