Effect of HELLP syndrome on acute kidney injury in pregnancy and pregnancy outcomes: a systematic review and meta-analysis
| Autor: | Yi-juan Chen, Shao-quan Zhang, Wen-qing Zhai, Guan-jun Ling, Qiang Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
HELLP Syndrome HELLP syndrome Reproductive medicine lcsh:Gynecology and obstetrics Risk Assessment 03 medical and health sciences 0302 clinical medicine AKI Pregnancy Risk Factors medicine Humans 030212 general & internal medicine lcsh:RG1-991 Pregnancy outcomes 030219 obstetrics & reproductive medicine business.industry Obstetrics Incidence (epidemiology) Incidence Acute kidney injury Pregnancy Outcome Obstetrics and Gynecology Acute Kidney Injury medicine.disease Meta-analysis Fetal Mortality Maternal Death Maternal death Female business Cohort study Research Article |
| Zdroj: | BMC Pregnancy and Childbirth BMC Pregnancy and Childbirth, Vol 20, Iss 1, Pp 1-9 (2020) |
| ISSN: | 1471-2393 |
| Popis: | Background HELLP syndrome may increase adverse pregnancy outcomes, though the incidence of it is not high. At present, the impact of HELLP syndrome on P-AKI (acute kidney injury during pregnancy) and maternal and infant outcomes is controversial. Thus, we conducted a meta-analysis to find out more about the relationship between HELLP syndrome and P-AKI and pregnancy outcomes. Methods We systematically searched PubMed, Embassy and Cochrane Databases for cohort studies and RCT to assess the effect of HELLP syndrome on P-AKI and maternal and infant outcomes. Study-specific risk estimates were combined by using fixed-effect or random-effect models. Results This meta-analysis included 11 cohort studies with a total of 6333 Participants, including 355 cases of pregnant women with HELLP syndrome and 5979 cases that without. HELLP syndrome was associated with relatively higher risk of P-AKI (OR4.87 95% CI 3.31 ~ 7.17, P Conclusions HELLP syndrome is associated with relatively higher risk of P-AKI, fetal mortality and maternal death. |
| Databáze: | OpenAIRE |
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