U.K. multicentre study on blood donors for surrogate markers of non-A non-B hepatitis. Part I: Alanine transferase and anti-HBc testing
| Autor: | A. Bendle, D. J. Goldie, M. Briggs, M. Contreras, K. H. Shwe, V. Mijovic, John A. J. Barbara, H. H. Gunson, N. A. B. Anderson, K. Paver, C. J. Seneviratne, V. Martlew, A. Raafat, I. D. Fraser |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Alcohol Drinking Physical Exertion Blood Donors Gastroenterology Risk Factors Internal medicine Alt measurement London medicine Prevalence Standard test Humans Mass Screening Hepatitis Antibodies Obesity Alanine aminotransferase Hepatitis B Antibodies Alanine transferase Aged Hemagglutination assay business.industry Incidence Radioimmunoassay Alanine Transaminase Hematology Hepatitis C Antibodies Middle Aged Hepatitis B Hepatitis B Core Antigens Hepatitis C digestive system diseases United Kingdom Anti hbc Immunology Non b hepatitis Female business Biomarkers Follow-Up Studies |
| Zdroj: | Transfusion medicine (Oxford, England). 2(4) |
| ISSN: | 0958-7578 |
| Popis: | SUMMARY. Blood samples from 9,215 blood donors in three U.K. centres (North London, Bristol and Manchester) were tested for their alanine aminotransferase (ALT) level and the presence of anti-HBc and anti-HCV. This paper presents the results of the ALT and anti-HBc tests. The prevalence of ALT >45 IU/1 was 3.1% overall (North London 3.06%, Bristol 4.56% and Manchester 1.97%). Manchester results were skewed by the methodology used for ALT measurement, highlighting the need for standard test methods. Anti-HBc was detected using the Wellcome enzymeimmunosorbent assay (EIA) and confirmatory testing was performed using a radioimmunoassay (RIA) and the Corecell haemagglutination assay. Repeat reactive rates were 0.9, 0.79 and 0.94% for North London, Bristol and Manchester, respectively, with an overall rate of 0.9%. The confirmed positive rate was 0.73, 0.53 and 0.65% for the three centres with an overall rate of 0.63%. Donors with an ALT >45 IU/1, or with confirmed anti-HBc, were interviewed with a medical questionnaire for risk factors. The major contributing factors in donors with a raised ALT were alcohol consumption and obesity. |
| Databáze: | OpenAIRE |
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