Recurrence of hepatocellular cancer after liver transplantation: The role of primary resection and salvage transplantation in East and West

Autor: WW Sharr, Gurusharan Singh, See Ching Chan, Jan Lerut, Quirino Lai, Massimo Rossi, Giuseppe Tisone, Salvatore Agnes, Chung Mau Lo, Tommaso Maria Manzia, Alfonso Wolfango Avolio, Kenneth S. H. Chok, Pasquale Berloco
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Adult
Male
medicine.medical_specialty
Carcinoma
Hepatocellular
WEST
medicine.medical_treatment
Settore MED/18 - CHIRURGIA GENERALE
Rome
Salvage therapy
LOCOREGIONAL THERAPY
Liver transplantation
Milan criteria
Model for End-Stage Liver Disease
Risk Factors
Carcinoma
medicine
Humans
Hepatology
Gastroenterology
hepatocelluar cancer
locoregional therapies
resection
salvage transplantation
Aged
Retrospective Studies
SALVAGE TRANSPLANTATION
Salvage Therapy
OUTCOME
RECURRENCE FREE SURVIVAL
business.industry
Incidence
Liver Neoplasms
Disease Management
Retrospective cohort study
LIVER TRANSPLANTATION
Odds ratio
MILAN CRITERIA
Middle Aged
medicine.disease
Prognosis
digestive system diseases
Surgery
Settore MED/18
Transplantation
Logistic Models
Treatment Outcome
EAST
SURVIVAL
Hong Kong
Female
Neoplasm Recurrence
Local
business
the role of primary resection and salvage transplantation
Popis: Greater tumor aggressiveness and different management modalities of hepatocellular cancer (HCC) before liver transplantation (LT) may explain the higher recurrence rates reported in Asia. This study investigates the prognostic factors for HCC recurrence in a Western and an Eastern HCC patient cohort in order to analyze the respective roles of tumor- and management-related factors on the incidence of post-LT HCC recurrence.Data of 273 HCC patients, transplanted during the period January 1999-March 2009, were obtained from the Rome Inter-University Liver Transplant Consortium (n=157) and Hong Kong University (n=116) databases. Median follow-up was 4.3 years (range: 0.2-12). Recurrence rate and multivariate logistic regression analysis was performed on the entire population and on Milan criteria-in (MC-in) patients.Multivariate analysis on the entire population identified four independent risk factors for post-LT HCC recurrence: microvascular invasion (odds ratio, OR=4.88; p=0.001), poor tumor grading (OR=6.86; p=0.002), diameter of the largest tumor (OR=4.72; p=0.05), and previous liver resection (LR) (OR=3.34; p=0.04). After removal of LR, only tumor-related variables were independent risk factors for recurrence. When only MC-in patients were analyzed, no difference was observed between the two cohorts in terms of recurrence rate after LR patient removal.LR followed by salvage "for HCC recurrence" LT represents the main reason for a higher HCC recurrence rate in the Hong Kong patients, but not LR followed by salvage "for liver failure" LT in the Roman group. This approach towards HCC before LT may not be universally applicable. The precise patient background must be taken into account in order to identify the best pre-LT strategy.
Databáze: OpenAIRE
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