'Randomised controlled trial of scalp cooling for the prevention of chemotherapy induced alopecia'
| Autor: | Arun Chandrasekharan, S. Kanan, Jaya Ghosh, Jyoti Bajpai, Sudeep Gupta, Y. Kembhavi, S. Dandekar, S. Kagwade, S D Banavali |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Quality of life
medicine.medical_specialty Scalp cooling Anthracycline medicine.medical_treatment Population Urology lcsh:RC254-282 law.invention 03 medical and health sciences 0302 clinical medicine Breast cancer Randomized controlled trial law Clinical endpoint Medicine Chemotherapy 030212 general & internal medicine education education.field_of_study Taxane business.industry Alopecia General Medicine lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Hair loss 030220 oncology & carcinogenesis Surgery Original Article business |
| Zdroj: | The Breast : official journal of the European Society of Mastology Breast, Vol 49, Iss, Pp 187-193 (2020) |
| ISSN: | 1532-3080 0960-9776 |
| Popis: | Background: Randomized controlled trials (RCT) of scalp cooling (SC) to prevent chemotherapy induced alopecia (CIA) did not evaluate its effect on hair regrowth (HR) and was conducted in a predominantly taxane (T) treated population. We conducted an RCT of SC in a setting of anthracycline (A) and taxane chemotherapy (CT) and assessed its effect on CIA and HR. Methods: Non-metastatic breast cancer women undergoing (neo) adjuvant CT were randomized to receive SC using the Paxman scalp cooling system during every cycle of CT, or no SC. The primary end point (PEP) was successful hair preservation (HP) assessed clinically and by review of photographs after CT. HR was assessed at 6 and 12 weeks. Results: 51 patients were randomized to SC (34) or control arm (17) in a 2:1 ratio. Twenty-five (49%) patients received A followed by T and the two arms were balanced with respect to this factor. HP rate was significantly higher in SC arm compared to control arm (56.3% vs 0%, P = 0.000004). HR was higher in SC arm compared to control at 6 weeks (89% vs 12%; P |
| Databáze: | OpenAIRE |
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