Neuroimaging Correlates of Emotional Response-Inhibition Discriminate Between Young Depressed Adults With and Without Sub-threshold Bipolar Symptoms
| Autor: | Bo Hu, Jeffrey M. Spielberg, Sidra L Speaker, Harish Karne, Murat Altinay, Parashar Koirala, Jungwon Cha, Amit Anand |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Audiology behavioral disciplines and activities 030227 psychiatry Bipolar disorder depression 03 medical and health sciences 0302 clinical medicine Neuroimaging mental disorders medicine Mixed effects Sub threshold Young adult medicine.symptom business Mania 030217 neurology & neurosurgery Response inhibition Depression (differential diagnoses) |
| Popis: | BackgroundA significant number of subjects with major depression (MDD) exhibit subthreshold mania symptoms (MDD+). This study investigated, for the first time, using emotional inhibition tasks, whether the neurobiology of MDD+ subjects is more akin to bipolar disorder depression (BDD) or to MDD subjects without any subthreshold bipolar symptoms (MDD−).MethodThis study included 118 medication-free young adult subjects (16 – 30 yrs.): 20 BDD, 28 MDD+, 41 MDD−, and 29 HC subjects. Participants underwent fMRI during emotional and non-emotional Go/No-go tasks during which they responded for Go stimuli and inhibited response for happy, fear, emotional (happy + fear) and non-emotional (gender) faces No-go stimuli. Linear mixed effects (LME) analysis for group effects and Gaussian Process Classifier (GPC) analyses was conducted.ResultsMDD− group compared to both the BDD and MDD+ groups, exhibited significantly lower activation in parietal, temporal and frontal regions (cluster-wise corrected p ConclusionUsing an fMRI emotional Go-Nogo task, MDD− subjects can be discriminated from BDD subjects and MDD+. |
| Databáze: | OpenAIRE |
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